| 规格： | 5mg | 产品价格： | 370 |
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| 规格： | 10mg | 产品价格： | 710 |
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| 规格： | 50mg | 产品价格： | 2980 |
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| 规格： | 100mg | 产品价格： | 5210 |
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Catalog Number GC15372
Synonyms 3-HPAA
Molecular Formula C26H37NO2
Relative Molecular Mass 395.6
CAS Registry Number 183718-75-4
Formulation A solid
Purity ≥98%
Storage Store at -20°C
SMILES CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)Nc1cccc(O)c1
产品描述
IC50: 2 μM N-(3-hydroxyphenyl) -Arachidonoyl amide, also known as 3-HPAA, is an analog of AM404 (N-(4-hydroxyphenyl)-arachidonoyl amide), a selective inhibitor of carrier-mediated transport of arachidonoyl ethanolamide. 3-HPAA, metabolized by both cyclooxygenase (COX) -1 and COX-2, is an irreversible and selective inhibitor of COX-2 with an IC50 value of 2 M. 3-HPAA can be efficiently oxygenated to prostaglandin and hydroxyeicosatetraenoate products by prostaglandin endoperoxide synthase (PGHS) -2. It appears that 3-HPAA can be converted by PGHS-1 in a similar manner. COX enzymes play elaborate roles in human physiology and pathology, involving neuronal, immune, renal, cardiovascular, gastrointestinal, and reproductive systems. COX enzymes are blocked by aspirin and a wide variety of other non-steroidal anti-inflammatory drugs, which makes them clinically important [1]. COX-2, overexpressed in cancer cells, promotes tumorigenesis and induces neo-angiogenesis. Additionally, it plays an important role in inflammation and pyrexia.In vitro: Up to now, in vitro study of 3-HPAA is still in the development stage.In vivo: Up to now, in vivo study of 3-HPAA is still in the development stage.Reference:[1]. Fitzpatrick, F. Cyclooxygenase Enzymes: Regulation and Function. Current Pharmaceutical Design. 2004; 10(6): 577-588.
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温馨提示：不可用于临床ZL。
