| 规格： | 1mg | 产品价格： | 230 |
|---|
| 规格： | 5mg | 产品价格： | 1030 |
|---|
| 规格： | 10mg | 产品价格： | 1820 |
|---|
| 规格： | 50mg | 产品价格： | 7980 |
|---|
Catalog Number GC14777
Molecular Formula C27H33ClN2O3
Relative Molecular Mass 469.0
CAS Registry Number 282728-65-8
Formulation A solid
Purity ≥98%
Storage Store at -20°C
SMILES ClC1=CC=C(C(N2C(C=CC(OC)=C3)=C3C(CC(N([H])CCCCCCCC)=O)=C2C)=O)C=C1
产品描述
Indomethacin N-octyl amide is a potent and non-selective inhibitor of both COX-1 and COX-2 [1].Cyclooxygenase (COX) is the key enzyme required for the conversion of arachidonic acid to prostaglandins. Cyclooxygenase enzymes have been involved in diverse physiological situations and disease processes ranging from inflammation to cancer. Until now, two cyclooxygenase isoforms have been identified, COX-1 and COX-2. The COX-1 enzyme is produced constitutively (i.e., gastric mucosa) and COX-2 is inducible (i.e., sites of inflammation) [2]. Indomethacin is a potent but non-selective inhibitor of both COX-1 and COX-2. Indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivitized as an ester or amide. Conversion of indomethacin into ester and amide derivatives provides a facile strategy for generating highly selective COX-2 inhibitors. Indomethacin N-octyl amide inhibited the activity of ovine COX-1 and human recombinant COX-2 with the IC50 values of 66 μM and 40 nM, respectively. While the IC50 of indomethacin for the inhibition of COX-1 and COX-2 were 0.67 μM and 0.05 μM, respectively [1].References:[1] Kalgutkar A S, Marnett A B, Crews B C, et al. Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors[J]. Journal of medicinal chemistry, 2000, 43(15): 2860-2870.[2] Dubois R N, Abramson S B, Crofford L, et al. Cyclooxygenase in biology and disease[J]. The FASEB journal, 1998, 12(12): 1063-1073.
更多产品信息，请点击：https://www.glpbio.cn/search.php?catalog=GC14777原装进口,Indomethacin N-octyl amide,美国GlpBio品Pai大包装更优惠!
美国Glpbio是一家领先的小分子YZ剂、激活剂、化合物库、多肽和实验室试剂的供应商。公司经营范围广泛，产品涉及癌症、免疫学、神经科学、细胞凋亡、表观遗传学等20多个不同研究领域，拥有10000多种产品。总部位于美国加利福尼亚，营销网点遍及法国、德国、加拿大、日本、澳大利亚、新加坡、以色列等20多个国家地区，竭诚为各国的科研工作者提供优质的产品和专业的服务。
温馨提示：不可用于临床ZL。
