Anti-IZUMO1R antibody

Anti-IZUMO1R antibody

Cat. No.     JC263930
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-IZUMO1R rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human IZUMO1R
Reactivity                 Human
Content                     1.2 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 IZUMO1R
Full name                 IZUMO1 receptor, JUNO
Synonyms    JUNO; FOLR4; Folbp3
Swissprot    A6ND01

Target Background
Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.

Applications
Immunohistochemistry
Predicted cell location: Cell membrane
Positive control: Human tonsil
Recommended dilution: 25-100    Predicted cell location: Cell membrane
Positive control: Human lung cancer
Recommended dilution: 25-100
            
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using ml263930(IZUMO1R Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)    The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using ml263930(IZUMO1R Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)

ELISA
Recommended dilution: 5000-10000