品Pai:miltenyi，产品名称：CD184 (CXCR4)-APC-Vio770, human
CD184 (CXCR4) antibodies, human - Miltenyi Biotec
货号：130-109-846
Clone REA649 recognizes the human CD184 antigen, a multi-pass membrane protein, also known as C-X-C chemokine receptor type 4 (CXCR4), leukocyte-derived seven transmembrane domain receptor (LESTR), or fusin. CD184 is ubiquitously expressed on blood and tissue cells. It mediates chemotaxis in mature and progenitor blood cells and is important for B lympho- and myelopoiesis and cardiogenesis. CD184 exclusively interacts with the endogenous ligand CXCL12. Binding of CXCL12 transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Although CXCL12 is the only known chemokine that binds CD184, recent studies suggest that extracellular ubiquitin also acts as an immune modulator through CD184-mediated signaling. CD184 is a co-receptor for HIV entry by promoting Env-mediated fusion of the virus.
Additional information: Clone REA649 displays negligible binding to Fc receptors.
| Clone | Isotype |
|---|---|
| REA649 | recombinant human IgG1 |
