品Pai:miltenyi，产品名称：CD209 (DC-SIGN)-Biotin, human 30 tests
CD209 (DC-SIGN) antibodies, human - Miltenyi Biotec
货号：130-109-646
Clone REA617 recognizes the CD209 antigen, also known as dendritic cell specific ICAM-3 grabbing non-integrin (DC-SIGN), a type II c-type lectin expressed in dermal and mucous tissue, lymphoid tissue such as tonsil, lymph node, spleen, as well as on monocyte-derived DCs (MoDCs). It is not expressed on DC subsets in peripheral blood, except for a subpopulation of CD14+ cells with a DC-like phenotype. DC-SIGN acts as an adhesion receptor to facilitate interactions between DCs and T cells or DCs and endothelial cells. In addition, it serves as an antigen receptor mediating internalization of ligands for antigen presentation, binding virus such as HIV, HCMV, or Ebola as well as parasites, bacteria, or yeast. HIV-1 uses this feature of DC-SIGN for efficient intrans infection of CD4+ T cells.
Additional information: Clone REA617 displays negligible binding to Fc receptors.
| Clone | Isotype |
|---|---|
| REA617 | recombinant human IgG1 |
