Qa-2-VioBlue/Anti-QA-2 antibodies, mouse

品Pai:miltenyi，产品名称：Anti-Qa-2-VioBlue, mouse 200 tests
Anti-QA-2 antibodies, mouse - Miltenyi Biotec
货号：130-107-905
Clone REA523 recognizes the mouse Qa-2 antigen, a 40 kDa single-pass type I membrane protein, which is also known as H-2 class I histocompatibility antigen Q7 alpha chain (H2-Q7). Qa-2 is a murine non-classical MHC class I molecule involved in the modulation of immune responses by interacting with T CD8⁺ and NK cell inhibitory receptors. The murine Qa-2 genes map to the H-2Q region, between the classical class I H-2D locus and the H-2TL cluster of class lb sequences. This locus encodes a variable number of class Ib genes in different strains. Strains expressing high (Qa-2^high), medium (Qa-2^med), low (Qa-2^low), and no Qa-2 (Qa-2^nul) were identified. Qa-2 is found as membrane-bound and soluble isoforms generated by alternative splicing. It is expressed mostly by lymphoid-derived cells and plays an important role in controlling growth and murine fetal development and, like HLA-G, the molecule is related to the protection of the fetus by inhibiting maternal NK cell-mediated lysis.
Additional information: Clone REA523 displays negligible binding to Fc receptors.

Alternative namesH2-Qa2, H2-Q7, H2-Q7

Clone and isotype

Clone	Isotype
REA523	recombinant human IgG1