品Pai:miltenyi，产品名称：CD135-PE-Vio770, mouse 200 tests
CD135 (FLT3) antibodies, mouse - Miltenyi Biotec
货号：130-105-823
Clone A2F10 binds the 150 kDa surface protein Fms-like tyrosine kinase receptor 3 (FLT3), also known as FLK-2/CD135. CD135 has functional and structural homology to the class-III-receptor tyrosine kinases that include the M-CSF-, KIT-, and PDGF-receptors. The receptor is expressed on progenitor cells in adult bone marrow, thymus, brain, testis, and placenta. All hematopoietic cells develop from CD135 negative hematopoietic stem cells (HSCs) through CD135 positive progenitor cells. In synergy with other growth factors like G-CSF, GM-CSF, SCF, and IL-3, ligation of CD135 with FLT3 ligand promotes the proliferation and differentiation of primitive hematopoietic stem cells. As a result early B cell lineage differentiation as well as expansion of monocytes and immature dendritic cells are stimulated.
| Clone | Isotype |
|---|---|
| A2F10 | rat IgG2aκ |
