品Pai:miltenyi，产品名称：Anti-Notch2-PE, human
Anti-Notch2 antibodies, human - Miltenyi Biotec
货号：130-096-977
Upon binding its membrane-bound ligand of the Delta-like or Jagged family members, the Notch receptor undergoes two proteolytic cleavage steps eventually releasing the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, where it activates transcription within a multiprotein complex. Notch2 is expressed on various hematopetic cells, including T cell precursors in the thymus and activated peripheral T cells. In addition, the altered expression of Notch2 in various leukemias, lymphomas and cancers has been reported.
| Clone | Isotype |
|---|---|
| MHN2-25 | mouse IgG2aκ |
