品Pai:miltenyi，产品名称：CD49d-PE, human
CD49d antibodies, human - Miltenyi Biotec
货号：130-093-282
CD49d, also known as the α4 integrin chain or VLA-4α chain, is a 150 kDa cell adhesion protein that is directly involved in mononuclear leukocyte trafficking. Dimerized with β7 integrin, the resulting α4β7 integrin binds VCAM-1 (CD106), MAdCAM-1, and fibronectin to facilitate the rolling of leukocytes along vascular epithelium. In T cells, on ligation of MAdCAM-1, α4β7 integrin also provides costimulation of T cell receptor/CD3–mediated signaling.
CD49d is expressed on most mononuclear leukocytes, both in circulation or in lymphoid or other tissues, as well as on eosinophils and basophils.
| Clone | Isotype |
|---|---|
| MZ18-24A9 | mouse IgG2bκ |
