CD146-Biotin/CD146 antibodies, human

品Pai:miltenyi，产品名称：CD146-Biotin, human
CD146 antibodies, human - Miltenyi Biotec
货号：130-092-852
Clone 541-10B2 recognizes the human CD146 antigen, also known as MUC18, MCAM, Mel‑CAM, and S-Endo-1. CD146 is a transmembrane glycoprotein belonging to the immunoglobulin superfamily and contains five extracellular immunoglobulin (Ig)-like domains.^1,2 CD146 possesses a limited tissue expression distribution, including endothelial cells, pericytes, smooth muscle cells, follicular dendritic cells, melanoma cells, and a sub-population of activated T lymphocytes.^1,3 CD146 is also expressed on marrow stromal cells (MSCs).⁴
CD146 functions as a Ca²⁺-independent cell adhesion molecule that is involved in heterophilic cell-cell interactions⁵, and may be involved in the extravasion and/or homing of activated T cells.³ CD146 expression in melanoma is also directly associated with tumor growth and metastasis.^6,7

Alternative namesMCAM, MUC18, Endo-CAM, Mel-CAM, S-endo

Clone and isotype

Clone	Isotype
541-10B2	mouse IgG1κ