Tom20 (D8T4N)

品Pai:CST，产品名称：Tom20 (D8T4N) Rabbit mAb #42406
英文名称：Tom20 (D8T4N) Rabbit mAb
Product name：Tom20 (D8T4N) Rabbit mAb #42406
Source：Rabbit
Sensitivity：Endogenous
MW(kDa)：33
Applications：WB , IP , IF ,
Purification： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human Tom20 protein.
Background： Mitochondria play a central role in cellular energy metabolism and are essential organelles in eukaryotes. In humans, 13 proteins are encoded by the mitochondrial genome while the vast majority of mitochondrial proteins are encoded by the nuclear genome. As a result, most mitochondrial proteins are synthesized as precursors in the cytoplasm and imported across mitochondrial membranes by one or more translocase protein complexes (1). The translocase of the outer mitochondrial membrane (TOM complex) facilitates the import of proteins through the outer mitochondrial membrane, while the complementary translocase of the inner membrane (TIM complex) is responsible for protein transport to the mitochondrial matrix. The TOM complex consists of the receptors Tom20, Tom22, and Tom70, and the channel-forming protein Tom40 (1). Tom20 is localized in the outer mitochondrial membrane and initially recognizes precursors with a presequence to facilitate protein import across the outer mitochondrial membrane (2). In a sequential process, recognition of the presequence by Tom20 is followed by tethering of the presequence to the Tom40 protein complex for efficient protein import (3).

Entrez-Gene Id

9804

Swiss-Prot Acc.

Q15388

Specificity / Sensitivity:

Tom20 (D8T4N) Rabbit mAb recognizes endogenous levels of total Tom20 protein.

Species Reactivity:

Human, Mouse, Rat, Monkey

Application	Dilutions
Western Blotting	1:1000
Immunoprecipitation	1:50
Immunofluorescence (Immunocytochemistry)	1:200

Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.