Survivin Blocking Peptide
- 品牌：CST
- 型号：Survivin Blocking Peptide
- 产地：美国
- 供应商：上海恒斐生物科技有限公司
- 供应商报价：￥1050
- 标签：Survivin Blocking Peptide、Survivin Blocking Peptide价格、Survivin Blocking Peptide厂家、Survivin Blocking Peptide、、上海恒斐生物科技有限公司
产品库
品Pai:CST，产品名称：Survivin Blocking Peptide #1037
英文名称：Survivin Blocking Peptide
Product name：Survivin Blocking Peptide #1037
Applications：IHC ,
Background： Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy (1). Survivin binds and inhibits caspase-3, controlling the checkpoint in the G2/M-phase of the cell cycle by inhibiting apoptosis and promoting cell division (2,3). This regulatory process requires the phosphorylation of survivin at Thr34 by p34 cdc2 kinase (4). Gene targeting using a Thr34 phosphorylation-defective survivin mutant, as well as antisense survivin, have been shown to inhibit tumor growth (5,6).
Use as a blocking reagent to evaluate the specificity of antibody reactivity in immunohistochemistry protocols. For immunohistochemistry, add twice the volume of peptide as volume of antibody used in 100 µl total volume. Incubate for a minimum of 30 minutes prior to adding the entire volume to the slide. Recommended antibody dilutions can be found on the relevant product data sheet.
Supplied in 20 mM potassium phosphate (pH 7.0), 50 mM NaCl, 0.1 mM EDTA, 1 mg/ml BSA, 5% glycerol and 1% DMSO. Store at –20°C.
This peptide is used to specifically block Survivin (71G4) Rabbit mAb #2808 reactivity.
