FITC标记的羟基类固醇脱氢酶3α/3α-羟类固醇脱氢酶Ⅰ抗体

FITC标记的羟基类固醇脱氢酶3α/3α-羟类固醇脱氢酶Ⅰ抗体

英文名称	Anti-HSD3a/FITC
中文名称	FITC标记的羟基类固醇脱氢酶3α/3α-羟类固醇脱氢酶Ⅰ抗体
别    名	3 alpha HSD1; 3-alpha-HSD1; 3-alpha-HSD; 3-alpha-hydroxysteroid dehydrogenase type I; AK1C4_HUMAN; AKR1C4; Aldo keto reductase family 1 member C4; Aldo-keto reductase family 1 member C4; CDR; Chlordecone reductase; DD-4; DD4; DD 4; C11; CDR; CHDR; Dihydrodiol dehydrogenase 4; HAKRA.
规格价格	100ul/2980元 购买        大包装/询价
说 明 书	100ul
研究领域	肿瘤  细胞生物  免疫学  转录调节因子
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Horse, Rabbit,
产品应用	IF=1:50-200   not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量	36kDa
性    状	Lyophilized or Liquid
浓    度	1mg/ml
免 疫 原	KLH conjugated synthetic peptide derived from human 3-alpha-HSD1
亚    型	IgG
纯化方法	affinity purified by Protein A
储 存 液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍	background: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]. Function: Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route. Subunit: Monomer. Subcellular Location: Cytoplasm. Tissue Specificity: Liver specific. DISEASE: Defects in AKR1C4 are a cause of 46,XY sex reversal type 8 (SRXY8) [MIM:614279]. A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. Note=AKR1C4 mutations may act as modifier of disease severity in SRXY8 patients. A splicing mutation resulting in loss of exon 2 has been found in affected individuals also carrying mutation Val-79 in AKR1C2 (PubMed:21802064). Similarity: Belongs to the aldo/keto reductase family. Database links: Entrez Gene: 1109 Human Omim: 600451 Human SwissProt: P17516 Human Unigene: 567245 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.