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MMP-2 Inhibitor I 基质金属蛋白酶（MMP）-2的可逆YZ剂

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  • 10335-69-0  MMP-2 Inhibitor I  基质金属蛋白酶（MMP）-2的可逆YZ剂  货号C5615MMP-2 Inhibitor I  基质金属蛋白酶（MMP）-2的可逆YZ剂化学性质
    CAS号 10335-69-0 SDF Download SDF
    别名 ​Matrix Metalloproteinase-2 Inhibitor I,cis-9-Octadecenoyl-N-hydroxylamide,Oleylhydroxamate
    化学名 N-hydroxy-9Z-octadecenamide
    SMILES ONC(CCCCCCC/C=C\CCCCCCCC)=O
    分子式 C18H35NO2 分子量 297.5
    溶解性 Soluble in DMSO 储存条件 Store at -20°C
    运输条件 SY装：蓝冰运输。
    其他可选规格：常温运输或根据您的要求用蓝冰运输。
    一般建议 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。
    MMP-2 Inhibitor I  基质金属蛋白酶（MMP）-2的可逆YZ剂产品描述

    MMP-2 Inhibitor I, a hydroxamate-based, long-chain fatty acid, is a reversible inhibitor of matrix metalloproteinase (MMP)-2.

    Matrix metalloproteinases (MMPs) have been involved in the degradation of extracellular matrix. MMPs contribute to long-term remodeling processes such as embryogenesis, tumor invasion, inflammation, angiogenesis, and wound healing. MMP-2, also known as gelatinase A or type IV collagenase, has been involved in regulating diverse cellular functions independent of its action on the extracellular matrix, including vascular tone, platelet aggregation, and mediation of the acute mechanical dysfunction of the heart immediately after ischemia and reperfusion [2]. Up-regulation of MMP-2 has been associated with tumor invasion and metastasis [3].

    MMP-2 Inhibitor I inhibited the activity of matrix metalloproteinase (MMP)-2 with the Ki value of 1.6 μM [1]. MMP-2 Inhibitor I attenuated cancer cell migration [3]. MMP-2 Inhibitor I had also been used to preserve blood-brain barrier function in a Wistar rat model of pneumococcal meningitis [4].

    MMP-2 Inhibitor I  基质金属蛋白酶（MMP）-2的可逆YZ剂References:
    [1] Berton A, Rigot V, Huet E, et al.  Involvement of fibronectin type II repeats in the efficient inhibition of gelatinases A and B by long-chain unsaturated fatty acids[J]. Journal of Biological Chemistry, 2001, 276(23): 20458-20465.
    [2] Wang W, Schulze C J, Suarez-Pinzon W L, et al.  Intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury[J]. Circulation, 2002, 106(12): 1543-1549.
    [3] Emmert-Buck M R, Roth M J, Zhuang Z, et al.  Increased gelatinase A (MMP-2) and cathepsin B activity in invasive tumor regions of human colon cancer samples[J]. The American journal of pathology, 1994, 145(6): 1285.
    [4] Barichello T, Generoso J S, Michelon C M, et al.  Inhibition of matrix metalloproteinases-2 and-9 prevents cognitive impairment induced by pneumococcal meningitis in Wistar rats[J]. Experimental Biology and Medicine, 2014, 239(2): 225-231.

    MMP-2 Inhibitor I  基质金属蛋白酶（MMP）-2的可逆YZ剂
    上海恒斐生物现货供应说明书及YZ剂详情请联系上海恒斐生物021-60493872  刘鑫 17317793691（微信同步）QQ845206284
    温馨提示：不可用于临床ZL。
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