免疫原： KLH conjugated synthetic peptide derived from human RGC32
适应物种： 详见说明书
宿主： 详见说明书
标记物： 详见说明书
抗体名： 补体应答基因32抗体使用说明书
抗体英文名： Anti-RGC32
保质期： 详见说明书
抗原来源： Rabbit
克隆性： 多克隆
目录编号： 详见说明书
级别： 详见说明书
靶点： 详见说明书
数量： 大量
供应商： 上海博湖
规格： 0.2ml/200μg
中文名称补体应答基因32抗体使用说明书 英文名称 Anti-RGC32 别名 Chromosome 13 open reading frame 15; KIAA0564; MGC87338; response gene to complement 32; Response gene to complement 32 protein; RGC 32; RGC32; RGCC_HUMAN. 补体应答基因32抗体使用说明书是用于化学反应、分析化验、研究实验、教学实验、化学配方使用的纯净化学品，产品品质，价格实惠，多种规格供应，售后完善。 浓度 1mg/1ml 规格 0.2ml/200μg 抗体来源 Rabbit 克隆类型 polyclonal 交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep 产品类型一抗 研究领域肿瘤细胞生物免疫学细胞周期蛋白 蛋白分子量 predicted molecular weight: 15kDa 性状 Lyophilized or Liquid 免疫原 KLH conjugated synthetic peptide derived from human RGC32 亚型 IgG 纯化方法 affinity purified by Protein A 储存液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 补体应答基因32抗体使用说明书产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 产品介绍 RGC32, also known as C13orf15, is a 137 amino acid protein that localizes to the cytoplasm, as well as to the nucleus and the centrosome. Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart and placenta, RGC32 functions to modulate the activity of cell cycle-specific kinases, thereby regulating cell cycle progression. Additionally, RGC32 may promote cell cycle arrest at the G2/M phase transition and is thought to inhibit the growth of glioma cells, possibly functioning as a tumor suppressor. Conversely, overexpression of RGC32 may promote cell replication and assist in the pathogenesis of malignancies, suggesting that RGC32 also participates in tumor transformation and progression. RGC32 activity is induced by complement activation and by p53 in response to DNA damage. Multiple isoforms of RGC32 exist as a result of alternative splicing events. Function : Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. Subunit : Interacts with SMAD3 (By similarity). Interacts with CDK1 and PLK1. Subcellular Location : Cytoplasm. Nucleus. Cytoplasm ?cytoskeleton ?centrosome. Note: Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase. Tissue Specificity : Detected in brain, heart and liver (at protein level). Highly expressed in liver, skeletal muscle, kidney and pancreas. Detected at lower levels in heart, brain and placenta. Detected in aorta endothelial cells. Overexpressed in colon, breast, prostate, bladder, lung, and ovarian cancer tissues. Database links : Entrez Gene: 28984 Human Omim: 610077 Human SwissProt: Q9H4X1 Human
