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苦鬼臼毒素 Picropodophyllotoxin

产品信息
  • 规格: 5mg 产品价格: ¥325.0
    规格: 25mg 产品价格: ¥895.0
    规格: 100mg 产品价格: ¥2850.0
    一种非竞争性IGF-1RYZ剂,IC50 :~ 1 nM。IGF-1R Inhibitor is an insulin-like, cell-permeable cis-cyclolignan compound that acts as a non-competitive, potent, and specific inhibitor of growth factor-I receptor kinase (IGF-1R; IC50 = 1 nM in cell-free kinase assay; ≤ 60 nM for cell viability and receptor autophosphorylation in melanoma cell lines). IGF-1R Inhibitor, PPP exhibits little effect towards IR, FGFR, PDGFR and EGFR, and exerts no effects on microtubules and DNA topoisomerase II. This product is the first inhibitor reported to discriminate between IGF-1R and IR, and has shown complete inhibition of IGF-1R-dependent tumor cell growth at 20 mg/kg/12 hr i.p. with minimum toxic effect.
    温馨提示:不可用于临床ZL。
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