Name:SIVmac251 (gp140)) Fragment (171-190)) ;
Sequence(Three Letter):H-Lys-Phe-Thr-Met-Thr-Gly-Leu-Lys-Arg-Asp-Lys-Thr-Lys-Glu-Tyr-Asn-Glu-Thr-Trp-Tyr-Cys-OH (trifluoroacetate salt);
Sequence(One Letter):LFTMTGLKRDKTKEYNETWYC;
Formula:C118H180N30O35S2;
M.W.:2643.04;
Size:1mg,5mg,10mg,50mg,100mg,1g;
Purity:80%,90%,95%,98%,99%;
Storage Temp:Store at -20°C. Keep tightly closed. Store in a cool dry place.;
Reference:K.A.Kent et al., AIDS, 5, 829 (1991);
Description:Two monoclonal antibodies (MAbs), reactive with the external envelope glycoprotein of the simian immunodeficiency virus of macaque monkey and displaying a cellfree virus-neutralizing activity, were generated. Epitope mapping of these MAbs permitted to delineate a neutralizing domain localized in the second variable region of the SIVmac251 gp105, between amino acids 171 and 188. This domain is enclosed in the above sequence. In addition, this neutralizing domain usually induces a specific humoral response in experimentally SIVmac-infected macaques.
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