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SMOC2分泌模块化钙结合蛋白2/平滑肌相关蛋白2抗体

产品信息
  • SMOC2分泌模块化钙结合蛋白2/平滑肌相关蛋白2抗体
    英文名称 SMOC2
    中文名称 分泌模块化钙结合蛋白2/平滑肌相关蛋白2抗体
    别    名 Secreted modular calcium binding protein 2; SMAP 2; SMAP2; SMOC 2; Smooth muscle associated protein 2; SPARC related modular calcium binding 2; dJ421D16.1; MST117; MSTP117; bA270C4A.1; bA37D8.1; dJ421D16.1 (novel thyroglobulin type 1 repeat containing protein); MSTP140; SMOC2_HUMAN.  
    规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价
    说 明 书 100ul  200ul
    研究领域 心血管  细胞生物  信号转导  生长因子和激素  转录调节因子  血管内皮细胞  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, 
    产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 （石蜡切片需做抗原修复） 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 47kDa
    细胞定位 细胞膜 细胞外基质 分泌型蛋白 
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human SMOC2:311-410/446 
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    PubMed PubMed
    产品介绍 background:
    SMOC 2 (Secreted modular calcium binding protein 2) is a secreted modular protein containing an EF hand calcium binding domain homologous to that in BM40. It consists of two thyroglobulin like domains, a follistatin like domain and a novel domain found only in the homologous SMOC 1. SMOC 1 and 2 form a separate group within the BM40 family. SMOC 2 is a glycoprotein with a calcium dependent conformation. SMOC 2 contains 2 EF hand calcium binding domains, 1 Kazal like domain and 2 thyroglobulin type I domains.

    Function:
    Promotes matrix assembly and cell adhesiveness. Can stimulate endothelial cell proliferation, migration, as well as angiogenesis. 

    Subunit:
    Binds various proteins from the extracellular matrix.

    Subcellular Location:
    Secreted, extracellular space, extracellular matrix, basement membrane.

    DISEASE:
    Defects in SMOC2 are the cause of dentin dysplasia typ1 (DTDP1) [MIM:125400]. A dental defect in which both primary and secondary dentitions are affected. The clinical crowns of both permanent and deciduous teeth are of normal shape, form and color in most cases, although they may be slightly opalescent and blue or brown. Teeth may be very mobile and exfoliate spontaneously because of inadequate root formation. On radiographs, the roots are short and may be more pointed than normal. Pulp chambers are usually absent except for a chevron-shaped remnant in the crown. Root canals are usually absent. 

    Similarity:
    Contains 2 EF-hand domains. 
    Contains 1 Kazal-like domain. 
    Contains 2 thyroglobulin type-1 domains. 

    SWISS:
    Q9H3U7

    Gene ID:
    64094

    Database links:

    Entrez Gene: 64094 Human

    Entrez Gene: 64074 Mouse

    Omim: 607223 Human

    SwissProt: Q9H3U7 Human

    SwissProt: Q8CD91 Mouse

    Unigene: 487200 Human

    Unigene: 30162 Mouse



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
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