| 规格： | 5mg | 产品价格： | 304.5 |
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| 规格： | 10mg | 产品价格： | 577.5 |
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| 规格： | 25mg | 产品价格： | 1375.5 |
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| 规格： | 50mg | 产品价格： | 2436 |
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Catalog Number 17922
Synonyms Rho Kinase Inhibitor III|ROCK Inhibitor III|Rockout
Molecular Formula C13H10N2
Relative Molecular Mass 194.2
CAS Registry Number 7272-84-6
Formulation A crystalline solid
λmax 221, 314 nm
Purity ≥98%
Storage -20°C
SMILES C12=CC=CC=C1NC=C2C3=CC=NC=C3
产品描述
Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. 3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay. It also inhibits ROCK-II and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.
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Cayman公司成立于1980年，在过去20多年的发展过程中，始终保持着为科研工作者提供高质、优价研究产品的宗旨。该公司目前可以提供13,138 多种生化和免疫试剂，涉及肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等研究领域。非常有特色的检测试剂盒包括类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等。
温馨提示：不可用于临床ZL。
