| 规格： | 1mg | 产品价格： | 1039.5 |
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| 规格： | 5mg | 产品价格： | 3118.5 |
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| 规格： | 10mg | 产品价格： | 5197.5 |
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Catalog Number 16137
Molecular Formula C6H13NO3 • C4H6O6
Relative Molecular Mass 297.3
CAS Registry Number 957230-65-8
Formulation A crystalline solid
Purity ≥95%
Storage -20°C
SMILES O[C@@H]1[C@@H](CO)CNC[C@H]1O.O[C@H](C(O)=O)[C@H](O)C(O)=O
产品描述
Isofagomine (D-tartrate) is a competitive inhibitor of human lysosomal β-glucosidase (Ki = 0.016-0.025 µM; IC50 = 0.06 µM). By interacting with the catalytic pocket of β-glucosidase it acts as a chemical chaperone that increases the amount of β-glucosidase by stabilizing and/or promoting the folding of the enzyme. Isofagomine (D-tartrate) has been shown to increase lysosomal β-glucosidase activity by 2- to 3-fold in mutant N370S Gaucher fibroblasts. This compound has been studied in the context of Gaucher disease, a lysosomal storage disorder resulting from substantial deficiency of β-glucosidase and recently identified as a parkinsonism risk factor.
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Cayman公司成立于1980年，在过去20多年的发展过程中，始终保持着为科研工作者提供高质、优价研究产品的宗旨。该公司目前可以提供13,138 多种生化和免疫试剂，涉及肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等研究领域。非常有特色的检测试剂盒包括类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等。
温馨提示：不可用于临床ZL。
