| 规格： | 500μg | 产品价格： | 1039.5 |
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| 规格： | 1mg | 产品价格： | 1974 |
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Catalog Number 24714
Synonyms NPY (13-36) (human, rat)
Molecular Formula C134H207N41O36S • XCF3COOH
Relative Molecular Mass 3000.4
Formulation A lyophilized powder
Purity ≥95%
Storage -20°C
SMILES NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@]([C@@H](C)O)([H])NC([C@@]([C@H](CC)C)([H])NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)NC([C@@H](NC([C@@H]1CCCN1[H])=O)C)=O)=O)CC(O)=O)=O)CCSC)=O)C)=O)=O)CC2=CC=C(O)C=C2)=O)CC3=CC=C(O)C=C3)=O)=O)C)=O)=O)=O)CC4=CN=CN4)=O)CC5=CC=C(O)C=C5)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC6=CC=C(O)C=C6)=O.FC(F)(C(O)=O)F
产品描述
Neuropeptide Y (NPY) (13-36) is a C-terminal fragment of NPY, a neuropeptide involved in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion. NPY (13-36) is an agonist of the NPY receptor Y2 with Ki values of 1.28 and 2.62 nM for the rat recombinant receptor in CHO cells and in rat jejunal crypt cell membranes, respectively. It inhibits forskolin-induced cAMP accumulation with EC50 values of 300, 2.2, >1,000, and 20 at Y1, Y2, Y4, and Y5 receptors, respectively, in vitro. NPY (13-36) inhibits basal short circuit currents (EC50 = ~2 µM) and electrical field stimulated-secretory responses in isolated rat jejunal mucosa (EC50 = ~200 nM) but does so less potently than NPY (Item Nos. 24716 | 15071). NPY (13-36) also reduces the frequency of spontaneous excitatory postsynaptic currents (EPSCs) in the CA3 region of hippocampal slices from wild-type but not Y5 receptor knockout mice.
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Cayman公司成立于1980年，在过去20多年的发展过程中，始终保持着为科研工作者提供高质、优价研究产品的宗旨。该公司目前可以提供13,138 多种生化和免疫试剂，涉及肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等研究领域。非常有特色的检测试剂盒包括类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等。
温馨提示：不可用于临床ZL。
