特别提示：包括重组人Leptin在内，本公司的所有产品仅可用于科研实验，严禁用于临床YL及其他非科研用途！
产品名称：重组人Leptin
英文名称：Recombinant Human Leptin
产品货号：GS4627
产品规格：200μg
分子量：Approximately 16.0kDa,a single non-glycosylated polypeptide chain containing 146 amino acids.
储存条件：冷冻（-20℃）
概述
Human Leptin plays a key role in regulating energy intake and energy expenditure,including appetite and metabolism.It is one of the most important adipose derived hormones.The Ob(Lep)gene(Ob for obese,Lep for leptin)is located on chromosome 7 in humans.The protein is manufactured primarily in the adipocytes of white adipose tissue,and the level of circulating leptin is directly proportional to the total amount of fat in the body.Leptin acts on receptors in the hypothalamus of the brain where it inhibits appetite by(1)counteracting the effects of neuropeptide Y(a potent feeding stimulant secreted by cells in the gut and in the hypothalamus);(2)counteracting the effects of anandamide(another potent feeding stimulant that binds to the same receptors as THC),and(3)promoting the synthesis of α-MSH,an appetite suppressant.This appetite inhibition is long-term,in contrast to the rapid inhibition of eating by cholecystokinin(CCK)and the slower suppression of hunger between meals mediated by PYY3-36.The absence of leptin(or its receptor)leads to uncontrolled food intake and resulting obesity.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 |
Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 |
＞97%by SDS-PAGE and HPLC analyses. |
| 来源 |
Escherichia coli. |
| 生物活性 |
Fully biologically active when compared to standard.The as determined by a chemotaxis bioassay using human Leptin R transfected BaF3 murine proB cells is less than 2ng/ml,corresponding to a specific activity of>5.0×105 IU/mg. |
| 成分 |
Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 |
Less than 1 EU/μg of rHuLeptin as determined by LAL method. |
| 复溶 |
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 |
VPIQKVQDDT KTLIKTIVTR INDISHTQSV SSKQKVTGLD FIPGLHPILT LSKMDQTLAV YQQILTSMPS RNVIQISNDL ENLRDLLHVL AFSKSCHLPW ASGLETLDSL GGVLEASGYS TEVVALSRLQ GSLQDMLWQL DLSPGC |
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