a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively
官网链接：http://eastinnobio.com/xfzhhwxl
医诺生物提供生物医学研究中Z常用的八十余种小分子药物！
|
产品标号 |
化合物 |
CAS 号 |
结构图 |
说明 |
规格和价格 |
|
EI-SM-076 |
A66 |
1166227-08-2 |
 |
a potent and specific p110α inhibitor with IC50 of 32 nM. |
规格：5mg 10mg 50mg 价格: ￥1120 ￥2100 ￥6360 |
|
EI-SM-042 |
ABT-263 (Navitoclax) |
923564-51-6 |
 |
a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM, and ≤1 nM, respectively. |
规格：5mg 10mg 25mg 价格: ￥790 ￥1310 ￥2430
|
|
EI-SM-031 |
AC480 (BMS-599626) |
714971-09-2 |
 |
a selective and potent inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM respectively. |
规格：5mg 25mg 价格: ￥1120 ￥3740 |
|
EI-SM-030 |
Afatinib (BIBW2992) |
439081-18-2 |
 |
irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively. |
规格：5mg 10mg 价格: ￥660 ￥1180 |
|
EI-SM-039 |
Alectinib (CH5424802) |
1256580-46-7 |
 |
a potent ALK inhibitor with IC50 of 1.9 nM, sensitive to L1196M mutation. |
规格：5mg 10mg 50m 价格: ￥1120 ￥1770 ￥5050 |
|
EI-SM-082 |
Alisertib (MLN8237) |
1028486-01-2 |
 |
a selective Aurora A inhibitor with IC50 of 1.2 nM. |
规格：5mg 10mg 50mg 价格: ￥790 ￥1380 ￥4400 |
|
EI-SM-064 |
Azacitidine |
320-67-2 |
 |
specifically inhibits DNA methylation by trapping DNA methyltransferases. |
规格：50mg 价格: ￥640 |
|
EI-SM-077 |
BEZ235(NVP-BEZ235) |
915019-65-7 |
 |
a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM, respectively. Inhibits ATR with IC50 of 21 nM. |
规格：50mg 100mg 价格: ￥720 ￥1120 |
|
EI-SM-078 |
BKM120 (NVP-BKM120, Buparlisib) |
944396-07-0 |
 |
a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively. |
规格：5mg 10mg 价格: ￥1120 ￥1970 |
|
EI-SM-054 |
Bortezomib (PS-341) |
179324-69-7 |
 |
a potent 20S proteasome inhibitor with Ki of 0.6 nM. |
规格：5mg 25mg 价格: ￥460 ￥1770 |
|
EI-SM-023 |
BIO |
667463-62-9 |
 |
a specific inhibitor of GSK-3α/β with IC50 of 5 nM, which activates Wnt signaling pathway. |
规格：10mg 50mg 价格: ￥970 ￥3740 |
|
EI-SM-036 |
Cabozantinib (XL184, BMS-907351) |
849217-68-1 |
 |
a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. |
规格：5mg 10mg 50mg 价格: ￥720 ￥1120 ￥3080 |
|
EI-SM-079 |
CAL-101 (Idelalisib, GS-1101) |
870281-82-6 |
 |
a selective p110δ inhibitor with IC50 of 2.5 nM. |
规格：10mg 50mg 价格: ￥790 ￥3080 |
|
EI-SM-056 |
Carfilzomib(PR171) |
868540-17-4 |
 |
an irreversible proteasome inhibitor with IC50 of <5 nM. |
规格：5mg 10mg 50mg 价格: ￥1120 ￥1770 ￥4400 |
|
EI-SM-040 |
Ceritinib (LDK378) |
1032900-25-6 |
 |
a potent inhibitor against ALK with IC50 of 0.2 nM. |
规格：5mg 50mg 价格: ￥970 ￥3080
|
|
EI-SM-002 |
CHIR99021 |
252917-06-9 |
 |
a potent, ATP-competitive & highly selective GSK-3 inhibitor, which inhibits GSK-3α and GSK-3β with IC50 of 10 nM and 6.7 nM, respectively |
规格：2mg 5mg 25mg 价格: ￥590 ￥1120 ￥3740 |
|
EI-SM-034 |
Crizotinib (PF2341066） |
877399-52-5 |
 |
a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM, respectively. |
规格：5mg 10mg 50mg 价格: ￥720 ￥1120 ￥3740 |
|
EI-SM-069 |
Dabrafenib（GSK2118436) |
1195765-45-7 |
 |
a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively. |
规格：5mg 10mg 20mg 价格: ￥590 ￥850 ￥1120
|
|
EI-SM-057 |
DAPT (GSI-IX) |
208255-80-5 |
 |
an inhibitor of γ-secretase and Notch, a γ-secretase substrate |
规格：5mg 10mg 25mg 价格: ￥460 ￥790 ￥1380
|
|
EI-SM-038 |
Dasatinib |
302962-49-8 |
 |
a novel, potent and multi-targeted inhibitor of Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively. |
规格：25mg 价格: ￥240 |
|
EI-SM-063 |
Decitabine |
2353-33-5 |
 |
a potent inhibitor of DNA methylation. |
规格：10mg 25mg 50mg 价格: ￥590 ￥1120 ￥2100 |
|
EI-SM-025 |
Dorsomorphin 2HCl |
1219168-18-9 |
 |
a potent and selective inhibitor of ATR kinase with IC50 of 5 nM |
规格：10mg 50mg 价格: ￥970 ￥3080 |
|
EI-SM-074 |
Doxorubicin (Adriamycin) |
25316-40-9 |
 |
an antibiotic agent and a DNA intercalator that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells |
规格：10mg 25mg 价格: ￥590 ￥1380 |
|
EI-SM-021 |
Everolimus (RAD001) |
159351-69-6 |
 |
an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM. |
规格：10mg 25mg 价格: ￥720 ￥1380 |
|
EI-SM-028 |
Erlotinib HCl (OSI-744) |
183321-74-6 |
 |
an EGFR inhibitor with IC50 of 2 nM. |
规格：100mg 500mg 价格: ￥970 ￥2430
|
|
EI-SM-050 |
Fludarabine |
21679-14-1 |
 |
a STAT1 activation inhibitor and a DNA synthesis inhibitor. |
规格：5mg 10mg 25mg 价格: ￥330 ￥640 ￥1250 |
|
EI-SM-011 |
GDC0941 |
957054-30-7 |
 |
a potent inhibitor of PI3Kα/δ with IC50 of 3 nM |
规格：5mg 10mg 50mg 价格: ￥790 ￥1120 ￥2430 |
|
EI-SM-018 |
Gefitinib |
184475-35-2 |
 |
an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively |
规格：100mg 250mg 价格: ￥330 ￥660 |
|
EI-SM-032 |
Imatinib (STI571) |
152459-95-5 |
 |
a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively |
规格：250mg 500mg 价格: ￥460 ￥790 |
|
EI-SM-001 |
IWR-1-endo |
1127442-82-3 |
 |
a Wnt/β-catenin inhibitor with an IC50 value of 180 nM. |
规格：5mg 10mg 价格: ￥460 ￥720 |
|
EI-SM-010 |
（+）-JQ-1 |
1268524-70-4 |
 |
a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2) |
规格：10mg 25mg 价格: ￥1770 ￥3740 |
|
EI-SM-029 |
Lapatinib |
231277-92-2 |
 |
a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively. |
规格：25mg 100mg 价格: ￥720 ￥1770 |
|
EI-SM-003 |
LDN193189 |
1062368-24-4 |
 |
a selective BMP signaling inhibitor,with IC50 of 5 nM and 30 nM for inhibition of the BMP type I receptors ALK2 and ALK3, respectively |
规格：2mg 5mg 价格: ￥720 ￥1050 |
|
EI-SM-044 |
Lenalidomide (CC-5013) |
191732-72-6 |
 |
a TNF-α secretion inhibitor with IC50 of 13 nM. |
格：10mg 价格: ￥250 |
|
EI-SM-007 |
LY2157299 |
700874-72-2 |
 |
a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM |
规格：5mg 10mg 价格: ￥1120 ￥1770 |
|
EI-SM-012 |
LY411575 |
209984-57-6 |
 |
a potent γ-secretase inhibitor with IC50 of 0.082 nM, which inhibits Notch cleavage with IC50 of 0.39nM |
规格：10mg 50mg 价格: ￥1210 ￥3940 |
|
EI-SM-017 |
LY294002 |
154447-36-6 |
 |
an inhibitor of PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM respectively |
规格：10mg 25mg 价格: ￥970 ￥1770 |
|
EI-SM-055 |
MG132 |
133407-82-6 |
 |
an inhibitor of proteasome with IC50 of 100 nM in a cell-free assay, and also inhibits calpain with IC50 of 1.2 μM. |
规格：5mg 25mg 100mg 价格: ￥330 ￥1120 ￥3080 |
|
EI-SM-086 |
Mitomycin C |
50-07-7 |
 |
an antineoplastic antibiotic by inhibiting DNA synthesis. |
规格：10mg 50mg 200mg 价格: ￥640 ￥1950 ￥3920 |
|
EI-SM-051 |
MK2206 |
1032350-13-2 |
 |
a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM. |
规格：5mg 10mg 25mg 价格: ￥720 ￥1120 ￥2430
|
|
EI-SM-061 |
ML324 |
1222800-79-4 |
 |
a selective inhibitor of jumonji histone demethylase (JMJD2) with IC50 of 920 nM. |
规格：10mg 50mg 价格: ￥640 ￥2080 |
|
EI-SM-052 |
Nilotinib (AMN-107) |
641571-10-0 |
 |
a Bcr-Abl inhibitor with IC50<30 nM. |
规格：25mg 100mg 价格: ￥460 ￥1380 |
|
EI-SM-033 |
Nintedanib (BIBF 1120) |
928326-83-4 |
 |
a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM respectively. |
规格：5mg 10mg 50mg 价格: ￥790 ￥1380 ￥4400 |
|
EI-SM-013 |
NUTLIN 3 |
890090-75-2 |
 |
a potent and selective Mdm2 (a ubiquitin protein ligase for p53) antagonist with IC50 of 90 nM |
规格：5mg 10mg 25mg 价格: ￥720 ￥1120 ￥2430 |
|
EI-SM-060 |
Olaparib (AZD2281, KU0059436) |
763113-22-0 |
 |
a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM. |
规格：10mg 25mg 100mg 价格: ￥460 ￥980 ￥2430 |
|
EI-SM-053 |
Paclitaxel |
33069-62-4 |
 |
a chemo drug and a microtubule polymer stabilizer with IC50 of 0.1 pM |
规格：10mg 50mg 价格: ￥460 ￥1770 |
|
EI-SM-072 |
Palbociclib (PD-0332991) HCl |
827022-32-2 |
 |
a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM, respectively. |
规格：5mg 10mg 价格: ￥720 ￥1120 |
|
EI-SM-059 |
Panobinostat (LBH589) |
404950-80-7 |
 |
a broad-spectrum HDAC inhibitor with IC50 of 5 nM. |
规格：10mg 50mg 价格: ￥590 ￥1770
|
|
EI-SM-080 |
Pazopanib |
444731-52-6 |
 |
a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively. |
规格：25mg 100mg 价格: ￥460 ￥1380 |
|
EI-SM-083 |
PD-1/PD-L1 inhibitor 1 |
1675201-83-8 |
 |
disrupts PD-1/PDL-1 interaction. |
规格：5mg 25mg 价格: ￥970 ￥3260 |
|
EI-SM-014 |
PD0325901 |
391210-10-9 |
 |
a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM |
规格：5mg 25mg 价格: ￥460 ￥1770 |
|
EI-SM-015 |
PD173074 |
219580-11-7 |
 |
a potent FGFR1 inhibitor with IC50 of ~25 nM, which also inhibits VEGFR2 with IC50 of 100-200 nM |
规格：5mg 10mg 价格: ￥460 ￥790 |
|
EI-SM-067 |
PD98059 |
167869-21-8 |
 |
a non-ATP competitive MEK inhibitor with IC50 of 2 μM. |
规格：5mg 10mg 价格: ￥540 ￥970 |
|
EI-SM-073 |
Pemetrexed |
150399-23-8 |
 |
an antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. |
规格：10mg 50mg 价格: ￥790 ￥3080 |
|
EI-SM-019 |
Rapamycin（sirolimus ） |
53123-88-9 |
 |
a specific mTOR inhibitor with IC50 of ~0.1 nM |
规格：5mg 25mg 价格: ￥460 ￥1770 |
|
EI-SM-047 |
Regorafenib（BAY73-4506） |
755037-03-7 |
 |
a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively. |
规格：25mg 价格: ￥1570 |
|
EI-SM-016 |
RG108 |
48208-26-0 |
 |
DNA methyltransferase Inhibitor with IC50 of 115 nM |
规格：10mg 50mg 价格: ￥750 ￥3140 |
|
EI-SM-043 |
RITA (NSC 652287) |
213261-59-7 |
 |
induces DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and also inhibits MDM2-p53 interaction by targeting p53. |
规格：5mg 10mg 价格: ￥1120 ￥1770 |
|
EI-SM-006 |
SAG |
912545-86-9 |
 |
A potent agonist of Hedgehog (Hh)/Smoothened(Smo) signalling with EC50 of 3nM |
规格：2mg 5mg 价格: ￥770 ￥1620 |
|
EI-SM-070 |
SB203580 |
152121-47-6 |
 |
a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and it blocks PKB phosphorylation with IC50 of 3-5 μM. |
规格：25mg 50mg 100mg 价格: ￥970 ￥1770 ￥2430 |
|
EI-SM-004 |
SB431542 |
301836-41-9 |
 |
a potent and selective inhibitor of ALK5 with IC50 of 94 nM |
规格：10mg 50mg 价格: ￥940 ￥3080 |
|
EI-SM-026 |
Sorafenib Tosylate |
284461-73-0 |
 |
a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively |
规格：5mg 10mg 50mg 价格: ￥970 ￥1440 ￥4400 |
|
EI-SM-071 |
SP600125 |
129-56-6 |
 |
a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM, respectively. |
规格：10mg 50mg 价格: ￥420 ￥1620 |
|
EI-SM-027 |
Sunitinib Malate |
341031-54-7 |
 |
a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, which also inhibits c-Kit. |
规格：100mg 价格: ￥970 |
|
EI-SM-037 |
SSR128129E |
848318-25-2 |
 |
an allosteric and selective FGFR1 inhibitor with IC50 of 1.9 μM. |
规格：5mg 20mg 价格: ￥640 ￥1770
|
|
EI-SM-022 |
Tacrolimus (FK506） |
104987-11-3 |
 |
binds to the immunophilin FKBP12; inhibits PP2B (calcineurin); reduces peptidyl-prolyl isomerase activity in T cells. |
规格：50mg 100mg 价格: ￥590 ￥1120 |
|
EI-SM-045 |
Thalidomide |
50-35-1 |
 |
Thalidomide inhibits an E3 ubiquitin ligase in CRBN-DDB1-Cul4A complex. It inhibits TNF α biosynthesis and bFGF-induced angiogenesis. It also induces apoptosis in human monocyte cultures, and suggested to inhibit HIV-1 replication. |
规格：200mg 价格: ￥530 |
|
EI-SM-049 |
Tofacitinib citrate(CP690550) |
540737-29-9 |
 |
a potent and selective inhibitor of JAK3 with IC50 of 1 nM. |
规格：5mg 25mg 价格: ￥390 ￥1350 |
|
EI-SM-065 |
Trametinib (GSK1120212) |
871700-17-3 |
 |
a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM. |
规格：5mg 10mg 价格: ￥660 ￥980 |
|
EI-SM-066 |
U0126-EtOH |
1173097-76-1 |
 |
a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM. |
规格：25mg 100mg 价格: ￥970 ￥3080 |
|
EI-SM-068 |
Vemurafenib (PLX4032, RG7204) |
918504-65-1 |
 |
a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM. |
规格：10mg 50mg 价格: ￥460 ￥1770 |
|
EI-SM-041 |
Venetoclax (ABT-199, GDC-0199) |
1257044-40-8 |
 |
a Bcl-2-selective inhibitor with Ki of <0.01 nM. |
规格：5mg 50mg 价格: ￥1770 ￥6360 |
|
EI-SM-008 |
Vismodegib(GDC0449) |
879085-55-9 |
 |
a potent and specific inhibitor of Hedgehog (Hh)/Smoothened(Smo) signaling with IC50 of 3nM |
规格：5mg 10mg 价格: ￥590 ￥1390 |
|
EI-SM-058 |
Vorinostat (suberoylanilide hydroxamic acid, SAHA) |
149647-78-9 |
 |
an HDAC inhibitor with IC50 of ~10 nM. |
规格：200mg 500mg 价格: ￥970 ￥1440 |
|
EI-SM-081 |
XAV-939 |
284028-89-3 |
 |
a selective inhibitor of Wnt/β-catenin signaling through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM. |
规格：10mg 25mg 50mg 价格: ￥460 ￥1120 ￥1770 |
|
EI-SM-005 |
Y27632 2hcl |
129830-38-2 |
 |
a selective Rho-kinase inhibitor |
规格：2mg 5mg 10mg 价格: ￥460 ￥790 ￥1120 |
|
EI-SM-046 |
YM155 |
781661-94-7 |
 |
a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM, also slightly inhibits the interaction of Survivin with XIAP. |
规格：5mg 10mg 25mg 价格: ￥460 ￥790 ￥1770 |
|
EI-SM-020 |
ZSTK-474 |
475110-96-4 |
 |
an inhibitor of class I PI3K isoforms, mostly PI3Kδ, with IC50 of 37 nM |
规格：10mg 50mg 价格: ￥460 ￥1770 |
