重组小鼠TIM-3(T细胞免疫球蛋白黏蛋白分子3) 重组蛋白

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名称：重组小鼠TIM-3(T细胞免疫球蛋白黏蛋白分子3) 重组蛋白
英文名：Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3
品Pai：百奥莱博
规格：10μg|50μg|500μg|1mg
编号：JN1502
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Arg20-Arg191在C端含有His标签。

TIM-3 质量控制：＞95%(还原性SDS-PAGE)

TIM-3 制剂：冻干品

TIM-3 保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

TIM-3 复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于TIM-3 ：
T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in the Th1-mediated immune response. TIM3 is expressed on the Th1 cells, CD8 T-cells, monocytes, and dendritic cells, but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosis of apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interaction with phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with an agonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is also regarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 (PD-1) as two important coinhibitory regulators of T cell responses, have been implicated with the T-cell dysfunction or exhaustion associated with chronic HBV infection including HBV-related HCC.

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重组小鼠TIM-3(T细胞免疫球蛋白黏蛋白分子3) 重组蛋白关键词：重组小鼠TIM-3,重组小鼠TIM-3蛋白,JN1502,重组小鼠T细胞免疫球蛋白黏蛋白分子3,重组TIM-3

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重组小鼠TIM-3(T细胞免疫球蛋白黏蛋白分子3) 重组蛋白关键词：重组小鼠TIM-3,重组小鼠TIM-3蛋白,JN1502,重组小鼠T细胞免疫球蛋白黏蛋白分子3,重组TIM-3


·重组小鼠催乳素受体(PRLR)(C端带Fc标签)
编号：JN1506
英文名称：Recombinant Mouse Prolactin receptor
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Gln20-Asp229在C端带有Fc标签。

Prolactin R质量控制：＞95%(还原性SDS-PAGE)

Prolactin R制剂：冻干品

Prolactin R保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

Prolactin R复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于Prolactin R：
The prolactin receptor (PRLR) is a member of the class I cytokine/lactogen receptor family which mediates the diverse cellular actions of prolactin in several tissues. PRLRs are expressed in normal and neoplastic human breast tissue, and in most breast cancer cells. PRLR contains an extracellular region that binds prolactin, a transmembrane region, and a cytoplasmatic region required for the activation of the Jak2–Stat5 signal transduction pathway by Prl which is essential for transcriptional activation of all known prolactin regulated genes. PRLRs have also been observed in ovarian follicular cells of mice, pigs, sheep, deer, and humans, as well as in luteal tissue in cow and horse ovaries. Furthermore, PRLR knockout mice exhibit failure of embryonic implantation, reduced number of mature oocytes, and low fertilization rates. Knockout females also display a reduced number of primary follicles.

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