Human GITR / TNFRSF18 Protein, Mouse IgG2a Fc Tag, low endotoxin

内毒素:
Less than 0.1 EU per μg by the LAL method.

纯度:
>95% as determined by SDS-PAGE.

活性:
Immobilized Human GITR Ligand, Fc Tag (Cat. No. GIL-H526a) at 5 μg/mL (100 μL/well) can bind Human GITR, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. GIR-H525a) with a linear range of 5-39 ng/mL (QC tested).

产品背景:
Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.

产品描述:
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 41.4 kDa. The protein migrates as 46-49 kDa and 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

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