Desmethylanethol trithione

产品名称：Desmethylanethol trithioneDesmethylanethol trithione生物活性：

ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, ADT-OH markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, ADT-OH improved functional outcomes in mice subjected to MCAO and tPA infusion. H2S donors reduced tPA-induced cerebral hemorrhage by possibly inhibiting the Akt-VEGF-MMP9 cascade. Administration of H2S donors has potential as a novel modality to improve the safety of tPA following stroke.

Desmethylanethol trithione制备储备液：

浓度溶解体积质量	1mg	5mg	10mg
1mM	2.1032mL	10.5159mL	21.0318mL
5mM	0.4206mL	2.1032mL	4.2064mL
10mM	0.2103mL	1.0516mL	2.1032mL
50mM	0.0421mL	0.2103mL	0.4206mL

Desmethylanethol trithione临床数据( 数据源于：http:// clinicaltrials.gov）

Conversion of different model animals based on BSA（Value based on data from FDA Draft Guidelines）


   Animal A (mg/kg)=Animal B（mg/kg）multiplied by    AnimalBm系数/AnimalAm系数
   For example, to modify the dose of resveratrol uesd for a mouse(22.4mg/kg) to a dose based on the BSA for a rat, multiply 22.4mg/kg by the Km factor for a mouse and zhen divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2mg/kg


   南京赛泓瑞生物科技有限公司是专业从事生化试剂、分子生物学试剂、实验耗材及实验仪器研发、销售、服务为一体的专业性生物科技公司。本着服务科学的理念，赛泓瑞建立了生命科学研究工具的研发、生产、销售及技术服务平台，现已有数万余种产品，并每年不断开发新产品，为广大的生命科学研究人员、医学、药学、农业、环保等的科研人员提供科研工具性产品及技术服务.
经营范围：YZ剂、ELISA试剂盒、原代细胞和细胞株、化学试剂、蛋白、抗体、分子试剂和试剂盒。