Rat Neuropilin-1 ELISA Kit
- 品牌：innov-research
- 型号：-20°C
- 产地：美国/英国
- 供应商：上海信裕生物科技有限公司
- 供应商报价：$495
- 标签：Rat Neuropilin-1 ELISA Kit、Rat Neuropilin-1 ELISA Kit价格、Rat Neuropilin-1 ELISA Kit厂家、Rat Neuropilin-1 ELISA Kit、、上海信裕生物科技有限公司
产品库
Catalog No.: IRKTAH5525
$495
Category: Assay and ELISA Kits
NRP1(Neuropilin 1) also known as NP1, NRP, BDCA4 or VEGF165R, is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF) and semaphorin family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion. By somatic cell hybrid analysis, the NRP1 gene was mapped to chromosome 10. NRP1 bounds PGF1 with lower affinity. NRP1-mediated interactions are a necessary element in the initiation of the primary immune response and offer another example, like that of agrin, of a molecule shared by neurologic and immunologic synapses. After T-cell contact with DC, T-cell NRP1 colocalized with CD3 in the immunologic synapse and, sometimes, also at the opposite pole of the T cell. Soluble NRP1 interacts in a homophilic fashion with NRP1 on both DC and T cells, and this binding can be inhibited by blocking antibodies to NRP1. Furthermore, selective NRP1 inhibition in this model suppressed neovascular formation substantially.
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