商品分类：多克隆抗体
产品概述：Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity).
靶点/蛋白：Human SORBS1. This antibody is expected to recognize all seven reported isoforms (NP_006425.2, NP_056200.1, NP_001030126.1, NP_001030127.1, NP_001030128.1, NP_079267.1 and NP_001030129.1).
来源：Goat
参考文献：Lin W.-H.,et al.Genomics 74:12-20(2001).Lebre A.-S.,et al.Hum. Mol. Genet. 10:1201-1213(2001).Lin W.-H.,et al.Hum. Mol. Genet. 10:1753-1760(2001).Vandenbroere I.,et al.Biochem. Biophys. Res. Commun. 300:494-500(2003).Gehmlich K.,et al.J. Mol. Biol. 369:665-682(2007).
特异性：Human, Mouse, Rat, Hamster, Monkey, Horse, Dog
别名：Sorbin and SH3 domain-containing protein 1, Ponsin, SH3 domain protein 5, SH3P12, c-Cbl-associated protein, CAP, SORBS1 (HGNC:14565)
应用：ELISA (1:16000), IHC-P (2.5 μg/ml),
简单描述：Goat Polyclonal SORBS1 / Ponsin Antibody (C-Terminus). Validated for use in IHC-P, E.
详情：FunctionPlays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity).Cellular_LocationCell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Cell junction, focal adhesion Nucleus. Nucleus matrix Note=Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation.Tissue_LocationDetected in skeletal muscle (at protein level). Widely expressed with highest levels in heart and skeletal muscle.
生物商城：http://www.annoron.com
办公电话：010-56256916
官方售后：400-965-8633
企业 QQ：3212874516、3198592576
地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层
温馨提示：不可用于临床ZL。
