商品分类：多克隆抗体
产品概述：Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2- exo-monooxygenase. The enzyme also hydroxylates etoposide.
靶点/蛋白：Human CYP3A4 / Cytochrome P450 3A4.
来源：Rabbit
参考文献：Molowa D.T.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:5311-5315(1986).Gonzalez F.J.,et al.DNA 7:79-86(1988).Beaune P.H.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:8064-8068(1986).Spurr N.K.,et al.Hum. Genet. 81:171-174(1989).Bork R.W.,et al.J. Biol. Chem. 264:910-919(1989).
特异性：Human, Mouse, Rat
别名：CYP3A4, Albendazole monooxygenase, Albendazole sulfoxidase, Cyp3a3, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 3A4, CP33, CP34, CYP3A, Cytochrome P450 NF-25, HLP, Nifedipine oxidase, Quinine 3-monooxygenase, NF-25, p450C3, Cytochrome P4 ...
应用：IHC-P (5 μg/ml), WB (1:500 - 1:2000),
简单描述：Rabbit Polyclonal CYP3A4 / Cytochrome P450 3A4 Antibody. Validated for use in WB, IHC-P.
详情：FunctionCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2- exo-monooxygenase. The enzyme also hydroxylates etoposide.Cellular_LocationEndoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane proteinTissue_LocationExpressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056) According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level).
生物商城：http://www.annoron.com
办公电话：010-56256916
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地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层
温馨提示：不可用于临床ZL。
