Extracellular-Targeted TRPV Channel Antibody Explorer Kit

Extracellular-Targeted TRPV Channel Antibody Explorer KitA Screening Package of Extracellular-Targeted TRPV Channel Antibodies Economically Priced
Cat #: AK-485
12 Vials

Alomone Labs is pleased to offer the Extracellular-Targeted TRPV Channel Antibody Explorer Kit (#AK-485). The Explorer Kit contains extracellular-targeted TRPV channel antibodies, ideal for screening purposes. All antibodies of this kit recognize TRPV channels in their extracellular domain, and are thus ideal for detecting the channels in living cells, under non-fixating and non-permeabilizing conditions. 

• Compounds
• Scientific Background

Extracellular-Targeted TRPV Channel Antibody Explorer KitScientific Background 

TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells.¹ The TRP channels have putative six-transmembrane domains (TM) with a pore domain between the fifth and the sixth TM, and all assemble as tetramers. Both the N- and the C-terminus of all TRPs are intracellular.³

According to IUPHAR, the TRP family is comprised of three main subfamilies on the basis of sequence homology; TRPC, TRPM and TRPV (to date, three additional subfamilies are also considered to belong to the TRP family: the TRPA, TRPML, and TRPP).^1-4 The TRPV subfamily consists of six members, TRPV1-6.⁵

References 

1. Montell, C. et al. (2002) Mol. Cell. 9, 229.
2. Clapham, D.E. (2003) Nature 426, 517.
3. Moran, M.M. et al. (2004) Curr.Opin.Neurobiol. 14, 362.
4. Clapham, D.E. et al. (2003) Pharmacol. Rev. 55, 591.
5. Gunthorpe, M.J. et al. (2002) Trends Pharmacol. Sci. 23, 183.