Anti-PYY(3-36) (peptide tyrosine-tyrosine amide, 3-36)

Anti-PYY(3-36) (peptide tyrosine-tyrosine amide, 3-36)

Cat. No.

ABS 051-04

Product name

Anti-PYY(3-36) (peptide tyrosine-tyrosine amide, 3-36)

Description

Mouse monoclonal antibody

Specificity

Peptide tyrosine-tyrosine amide (3-36), or PYY(3-36), is a major metabolite of the gut hormone PYY and is produced by the action of dipeptidyl peptidase IV on PYY in the intestinal brush border and in the circulation. PYY(3-36) is a potent inhibitor of food intake in rats and humans, acting selectively on the Y2 receptor to inhibit orexigenic NPY neurons in the arcuate nucleus, thus disinhibiting anorexigenic POMC neurons. The anorexigenic effect of PYY(3-36) is additive to that of the co-secreted gut hormone GLP-1.

Immunogen

Synthetic N-terminal fragment of human PYY(3-36) coupled to carrier

Application

ELISA, WB

Species reactivity (positive)

Human

Species reactivity (negative)

Mouse, rat, dog, pig

Subclass

IgG1/k

Gene ID

5697

Clone number

04

Epitope

The epitope lies within residues 3-12 of human PYY

Content

Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.

Purification

Protein-A purified

Form

Liquid

Solvent

0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide

Storage

4-8ºC without exposure to light. No precautions necessary during handling.

Target

Peptide tyrosine-tyrosine amide (3-36), or PYY(3-36), is a major metabolite of the gut hormone PYY and is produced by the action of dipeptidyl peptidase IV on PYY in the intestinal brush border and in the circulation. PYY(3-36) is a potent inhibitor of food intake in rats and humans, acting selectively on the Y2 receptor to inhibit orexigenic NPY neurons in the arcuate nucleus, thus disinhibiting anorexigenic POMC neurons. The anorexigenic effect of PYY(3-36) is additive to that of the co-secreted gut hormone GLP-1.