内皮素-1 ≥97.0% (HPLC)
- 品牌：江蓝纯
- 型号：117399-94-7
- 供应商：江西江蓝纯生物试剂有限公司
- 供应商报价：¥2999 - 7999
- 标签：内皮素-1 ≥97.0% (HPLC)、内皮素-1 ≥97.0% (HPLC)价格、内皮素-1 ≥97.0% (HPLC)厂家、Endothelin 1、、江西江蓝纯生物试剂有限公司
产品库
| 规格： | 1mg | 产品价格： | ¥2999.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ¥7999.0 |
| 密度 | 1.1300 |
| 存贮条件 | 储存温度 -20°C |
| 产品介绍 | Amino Acid Sequence:Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp [Disulfide Bridges: 1-15; 3-11]. Endothelin-1 (ET-1) is synthesized and secreted by activated endothelial cells, and is a peptide with potent vasoconstrictor activity. It is a marker for activated or dysfunctional endothelial cells. This peptide is one of the three isopeptides belonging to the endothelin family. It is also released by cardiomyocytes. |
| 别名 | ;ET-1 H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH |
| 生化机理 | Endothelin-1 (ET-1) is a vasoconstrictor, which is increased in plasma and explants of patients with uterine leiomyomas. Thus, uterine fibroids are linked to increased ET-1 levels and hypertension, which is worsened by hypoxic condtions. ET-1 RNAi and Endostar are capable of preventing the progression and invasiveness of PC-3 (prostate cancer) cells. The plasma levels of this peptide are increased in patients with atrial septal defect (ASD), and these levels might help in diagnosis of closure defects. The plasma level of ET-1 is also higher in patients with end-stage renal disease (ESRD), and this is linked to gradual worsening of pulmonary function tests. Potent agonist for ETA and ETB endothelin receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF. |
| 应用 | 带有人类和猪内皮素1序列的合成肽。生物来源是带有相同序列的人内皮素 ETA 和 ETB内皮素受体激动剂。诱导缺氧诱导因子1α血管内皮生长因子的生产。 |
