797-63-7左炔诺孕酮

Hexestrol
分子式：C18H22O2
分子量：270.37
产品描述
Hexestrol 与ERα和ERβ结合，EC50分别为0.07 nM 和 0.175 nM。

靶点

ERαERβ IC500.07 nM (EC50)0.175 nM (EC50)
体外研究
Hexestrol binds to ERα with EC50 of 0.07 nM and to ERβ with EC50 of 0.175 nM.Hexestrol inhibits activity of AKR1B13 with IC50 of 3.2 μM.Hexestrol inhibits the d-galactose dehydrogenase activity of thermophilus aldose 1-dehydrogenase with IC50 of 0.063 mM.Hexestrol inhibits the dehydrogenase activity of AKR1C20 towards 10 μM 4-androsten-3α-o1-17-one with IC50 values of 2.7 μM.Hexestrol inhibits 17HSD5 with IC50 of 30 µM, and inhibits TBER1 with IC50 of 0.8 µM.Hexestrol reacts with DNA through the catechol quinone, thus can be a carcinogen.
体内研究
Hexestrol administered intraperitoneally at dose of 6 mg/kg may decrease ovulation in mice, as evident by smaller ovaries and decreased luteal bodies and oocytes.溶解性DMSO 42 mg/mL，水 <1 mg/mL，乙醇 42 mg/mL
稳定性
2年 -20°C粉状，6月-80°C溶于DMSO
特征
Much higher ERβ binding selectivity than Erα