PML/RARA Dual Color, Dual Fusion Translocation Probe

The reciprocal and balanced t(15;17), involving the PML (promyelocytic leukemia) gene on chromosome 15q22 and the RARA (retinoic acid receptor alpha) gene on chromosome 17q12.1 is a characteristic molecular feature of certain types of leukemia. Two gene fusion products result from this translocation, each of which encodes a functional chimeric protein: PML/RARA and RARA/PML.The breakpoints in the 15q22 region of chromosome 15 occur within a 13 kb region of the PML gene that contains three breakpoint cluster regions (bcr): bcr 3 extends from intron 3 through the 5' end of intron 4, bcr 2 extends from exon 5 to exon 6, and bcr 1 extends from intron 6 into exon 7. Break frequency is highest in bcr 1, followed by bcr 3 and bcr 2. The breakpoints on chromosome 17 occur within the approximately 17 kb intron 2 of the RARA gene. Know more at: http://www.creative-bioarray.com/PML-RARA-Dual-Color,-Dual-Fusion-Translocation-Probe-FHPC-089-item-4730.htm