产品库
登录
首页 找仪器 社区 百科 新品 供应商 品牌 应用 资料 仪企号 展会 标准 求购 招中标

2-(2-氯苯基)-5,7-二羟基-8-[(3S,4R)-3-羟基-1-甲基-4-啶哌基]苯并吡喃-4-酮

产品信息


  • 供应商：上海经科化学科技有限公司 


    服务热线：400-0199-638 


    QQ:472482400(上海经科）


    微信号：shjkchem 


    活动：消费积分可换充值卡！


    本试剂(2-(2-氯苯基)-5,7-二羟基-8-[(3S,4R)-3-羟基-1-甲基-4-啶哌基]苯并吡喃-4-酮)
    仅供科研实验使用,不得用于其他用途！
     

    简介：
    货 号：LC1-A-3465
    名   称：2-(2-氯苯基)-5,7-二羟基-8-[(3S,4R)-3-羟基-1-甲基-4-啶哌基]苯并吡喃-4-酮
    别   名：Alvocidib Free Base
    C A S ：146426-40-6
    分子量    ：401.84
    分子式：C21H20ClNO5
    纯   度：HPLC/TLC:>99%
    说   明：Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Disposal: A.
    文   献    ：Alvocidib is a broad-spectrum inhibitor of CDKs and targets their ATP binding sites. It promotes cell cycle arrest and apoptosis, induces differentiation, blocks transcription elongation, and inhibits angiogenesis. Senderowicz, A.M. "Small-molecule cyclin-dependent kinase modulators." Oncogene 22: 6609-6620 (2003).Administration of flavopiridol to older (>70 years) chronic lymphocytic leukemia patients is feasible, tolerable, and has comparable efficacy to that in younger patients (<70 years). Stephens, D.M., et al. "Flavopiridol treatment of patients aged 70 or older with refractory or relapsed chronic lymphocytic leukemia is a feasible and active therapeutic approach." Haematologica 97: 423-427 (2012).Preclinical studies have shown that alvocidib induces apoptosis in both normal and malignant cells, particularly those of hematopoietic origin. Arguello, F., et al. "Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity in vivo against human leukemia and lymphoma xenografts." Blood 91: 2482-2490 (1998).Alvocidib potentiates paclitaxel-induced apoptosis in the human gastric and breast cancer cell lines MKN-74 and MCF-7. Motwani, M., et al. "Sequential dependent enhancement of caspase activation and apoptosis by flavopiridol on paclitaxel-treated human gastric and breast cancer cells." Clin. Cancer Res. 5: 1876-1883 (1999).Alvocidib (100-200 nM) potentiates phorbol 12-myristate 13-acetate (PMA, 10 nM)-induced apoptosis in human myeloid leukemia cells U937 and HL-60. Cartee, L., et al. "Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways." Mol. Pharmacol. 61: 1313-1321 (2002).In early clinical trials, alvocidib demonstrated limited activity in patients with gastric carcinoma and lung cancer. Schwartz, G.K., et al. "Phase II Study of the Cyclin-Dependent Kinase Inhibitor Flavopiridol Administered to Patients With Advanced Gastric Carcinoma." J. Clin. Oncol. 19: 1985-1992 (2001). Shapiro, G.I., et al. "A Phase II Trial of the Cyclin-dependent Kinase Inhibitor Flavopiridol in Patients with Previously Untreated Stage IV Non-Small Cell Lung Cancer." Clin. Cancer Res. 7: 1590-1599 (2001).In vitro, alvocidib inhibited proliferation of human and mouse synovial fibroblasts. In vivo, treatment with alvocidib suppressed synovial hyperplasia and joint destruction in mice with collagen-induced arthritis. Sekine, C., et al. "Successful treatment of animal models of rheumatoid arthritis with small-molecule cyclin-dependent kinase inhibitors." J. Immunol. 180: 1954-1961 (2008).Alvocidib has potent antiviral activity in vitro againest HIV-1 and HSV-1. Schang, L.M. "Effects of pharmacological cyclin-dependent kinase inhibitors on viral transcription and replication." Biochim. Biophys. Acta. 1697: 197-209 (2004).
     
    温馨提示：不可用于临床ZL。
    • 信息声明：本产品供应信息由仪器网为您整合，供应商为（上海经科化学科技有限公司），内容包括 （2-(2-氯苯基)-5,7-二羟基-8-[(3S,4R)-3-羟基-1-甲基-4-啶哌基]苯并吡喃-4-酮）的品牌、型号、技术参数、详细介绍等；如果您想了解更多关于 （2-(2-氯苯基)-5,7-二羟基-8-[(3S,4R)-3-羟基-1-甲基-4-啶哌基]苯并吡喃-4-酮）的信息，请直接联系供应商，给供应商留言！
    供应商产品推荐
      您可能感兴趣的产品