| Description |  | Affinity Purified Biotinylated Polyclonal Antibody against Beta Amyloid (Aβ) 42 (Formerly Signet Catalog No.: 9137-005) |
| Intended Use | | **Research Use Only (RUO)** This product is sold for laboratory research use only, not for human or in-vivo use. |
| Form | | Biotin Labeled Affinity Purified (Stored in PBS + 50% Glycerol; no preservatives or carrier proteins) |
| Host | | Rabbit |
| Specificity | | Beta Amyloid 42 Polyclonal Antibody, Biotin Labeled (SIGNET)Covance’s biotinylated rabbit anti beta amyloid (Aβ) 42 antibody is specific for the C-terminus of Aβ 42. The rabbit anti Aβ 42 reacts extremely well with the 42 isoform. The rabbit anti Aβ 42 antibody does not cross-react with Aβ 40 or APP. Altered levels of Aβ isoforms, specifically the Aβ 40 and Aβ 42, have been shown in the brain tissues and CSF of Alzheimer’s disease patients. This antibody was generated against a peptide conjugated to keyhole limpet hemocyanin. |
| Uses | | This antibody is effective in immunoblotting and immunohistochemistry (IHC). |
| Suggested Working Dilution | | The optimal working dilution should be determined for each specific assay condition.
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| Storage | | Do not store antibody diluted below 50 ug/mL in the absence of protein (i.e.: add 2% bovine serum albumin). The antibody is best stored undiluted at -20°C to -70°C. |
| References | | Mehta PD, et al. Amyloid beta protein 40 and 42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease. Neurosci Lett 304(1-2):102-6, 2001. Schupf N, et al. Elevated plasma amyloid beta-peptide 42 and onset of dementia in adults with Down syndrome. Neurosci Lett 301(3):199-203, 2001. Beta Amyloid 42 Polyclonal Antibody, Biotin Labeled (SIGNET)Mehta PD, et al. Plasma and cerebrospinal fluid levels of amyloid beta proteins 40 and 42 in Alzheimer disease. Arch Neurol 57(1):100-5, 2000. Tapiola T, et al. Relationship between apoE genotype and CSF beta-amyloid (42) and tau in patients with probable and definite Alzheimers disease. Neurobiol Aging 21(5):735-40, 2000. Emmerling MR, et al. Traumatic brain injury elevates the Alzheimers amyloid peptide A beta 42 in human CSF. A possible role for nerve cell injury. Ann NY Acad Sci 903:118-22, 2000. Potempska A, et al. Quantification of sub-femtomole amounts of Alzheimer amyloid beta peptides. Amyloid 6(1):14-21, 1999. Mayeux R, et al. Plasma amyloid beta-peptide 42 and incipient Alzheimers disease.Ann Neurol 46(3):412-6, 1999. |
| Warranty/Conditions | | Covance products may not be resold or modified for resale without prior written approval. |
