Spectrin Binding Protein Monoclonal Antibody (SIGNET)

• Spectrin Binding Protein Monoclonal Antibody (SIGNET)保存于运输说明：
• Store at -20°C or below

• 详细信息：

• Description		Monoclonal Antibody against Spectrin Binding Protein (Formerly Signet Catalog Nos: 9710-02, 9710-05, 9710-10)
  Intended Use		**Research Use Only (RUO)** This product is sold for laboratory research use only, not for human or in-vivo use.
  Clone		4E2
  Form		Purified Antibody (in PBS; no preservatives or carrier proteins)
  Host		Spectrin Binding Protein Monoclonal Antibody (SIGNET)Mouse
  Species Reactivity		Human, Rat, Mouse
  IsoType		IgG2b
  [Ab]		1 mg/mL
  Specificity		Signet’s anti- human spectrin binding protein (clone 4E2) was developed against the spectrin SH3 domain binding protein Hssh3bp1 (Ziemnicka-Kotula et al., 1998). Hssh3bp1 is a marker of macropinocytic vesicles and a potential regulator of macropinocytosis (Xu et al., 2000). This antibody was developed against recombinant Hssh3bp1 (human spectrin SH3 domain binding protein 1).
  Uses		This antibody is effective in immunoblotting, immunofluorescence (IF) and immunohistochemistry (IHC).
  Suggested Working Dilution		The optimal working dilution should be determined for each specific assay condition. Western: 1:1,000-1:2,000 IF: 1:100-1:500 IHC: 1:40-1:100 Tissue Sections: Formalin fixed, paraffin embedded sections and frozen sections Pretreatment: For optimal staining, the sections should be pretreated with an antigen unmasking solution such as Retrieve-All 1 (SIG-31910). Incubation: Overnight at 4°C.
  Notes		Spectrin Binding Protein Monoclonal Antibody (SIGNET)Positive tissue (human): Prostate
  Storage		Store at -20°C or below. Upon initial thawing, apportion into working aliquots and store at -20°C or below. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Do not store in frost-free freezers.
  References		Macoska JA, et al. Loss of expression of human spectrin Src homology domain binding protein 1 is associated with 10p loss in human prostatic adenocarcinoma. Neoplasia. 3:1-6, 2001. Xu J, et al. Human spectrin SH3 domain binding protein 1 regulates macropinocytosis in NIH 3T3 cells. J Cell Science 113:3805-3814, 2000. Ziemnicka-Kotula D, et al. Identification of a candidate spectrin SH3 binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton. J Biol Chem 273:13681-13692, 1998. De Matteis, MA, Morrow JS. Spectrin tethers and mesh in the biosynthetic pathway. J Cell Science 113:2331-2343, 2000. Swanson JA, Watts C. Macropinosytosis. Trends Cell Biol 5:424-427, 1995. Lamaze C, Schimid SL. The emergence of clathrin-independent pinocytic pathways.Curr Opin Cell Biol 7:573-580, 1995. Bennett V, Gilligan DM. The spectrin-based membrane skeleton and micron scale organization of the plasma membrane. Annu Rev Cell Biol 9:27-66, 1993.
  Warranty/Conditions		Covance products may not be resold or modified for resale without prior written approval.

• Spectrin Binding Protein Monoclonal Antibody (SIGNET)
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