Endoglin (CD105) Clone SN6h Monoclonal Antibody, Purified (Signet)

• Endoglin (CD105) Clone SN6h Monoclonal Antibody, Purified (Signet)详细信息：

• Description		Purified Monoclonal antibody against endoglin (CD105) clone SN6h
  Intended Use		**Research Use Only (RUO)** This product is sold for laboratory research use only, not for human or in-vivo use.
  Clone		SN6h
  Form		Protein G Purified Antibody (in PBS + 0.1% NaN3 + 1% BSA)
  Host		Mouse
  Species Reactivity		Endoglin (CD105) Clone SN6h Monoclonal Antibody, Purified (Signet)Human
  IsoType		IgG1
  Specificity		Endoglin (CD-105) is a type I membrane glycoprotein that is part of the TGF beta receptor complex.  Endoglin (CD 105) is expressed in vascular endothelial tissue as well as a variety of other tissues. Endoglin may also be involved in the cytoskeletal organization affecting cell morphology and migration. (2) For formalin fixed paraffin embedded tissue sections, Covance recommends using the endoglin antibody with a polymer detection system such as Covance’s ACUITYAdvanced Polymer (SIG-32902). Concentrated Format: SIG-3770-1000 (1 mL)  Prediluted Format: SIG-3770-26 (6 mL) is ready to use with polymer detection such as ACUITYAdvanced Biotin free Polymer Detection (SIG-32902).
  Uses		This antibody is effective in immunohistochemisty on formalin fixed paraffin embedded sections. This antibody has been developed for use with a polymer detection kit such as ACUITYAdvanced Polymer Detection (SIG-32902).
  Suggested Working Dilution		Endoglin (CD105) Clone SN6h Monoclonal Antibody, Purified (Signet)The optimal working dilution should be determined for each specific assay condition. IHC: 1:100 (concentrated format) with Biotin free, polymer detection systems such as ACUITYAdvanced Polymer Detecton (SIG-32902). This antibody is not recommended for use with biotin based, non-polymer kits. Tissue Sections: Formalin-fixed, paraffin-embedded tissues Pretreatment: Protease 8 for 10 minutes at room temperature. Incubation: 60 minutes
  Storage		Store between 2-8°C.
  References		(1) C Li, R Grady, BK Seon, SE Duff, S Abdalla, A Renehan, ST ODwyer, N Haboubi, S Kumar. Both high intratumoral microvessel density determined using CD105 antibody and elevated plasma levels of CD105 antibody in colorectal cancer patients correlate with poor prognosis. Br J Cancer 88:1424-1431, 2003. (2) Sanz-Rodriguez, Francisco, et al. Endoglin regulates cytoskeletal organization through binding to ZRP-1 a member of the Lim family of proteins. J Biol Chem 279(31):32858-68, 2004.
  Warranty/Conditions		Covance products may not be resold or modified for resale without prior written approval.

• Endoglin (CD105) Clone SN6h Monoclonal Antibody, Purified (Signet)
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