| Description |  | Beta Amyloid (Aβ) Monoclonal Antibody, 6E10 Covance is the Exclusive Provider of this Antibody Product |
| Intended Use | | **Research Use Only (RUO)** This product is sold for laboratory research use only, not for human or in-vivo use. |
| Clone | | Beta Amyloid, 1-16 (6E10) Monoclonal Antibody Low Endotoxin, Purified Exclusively Provided by Covance6E10 |
| Form | | Protein G Purified Antibody (in PBS; no preservatives or carrier proteins)Endotoxin level < 0.5 EU/mL |
| Host | | Mouse |
| Species Reactivity | | Human |
| IsoType | | IgG1 |
| [Ab] | | 1 mg/mL |
| Specificity | | This antibody is reactive to amino acid residue 1-16 of beta amyloid. The epitope lies within amino acids 3-8 of beta amyloid (EFRHDS). Beta amyloid forms are deposited in the CNS of patients with Alzheimer’s disease and Down’s syndrome. Covances beta amyloid antibody 6E10 reacts to the abnormally processed isoforms, as well as precursor forms. |
| Uses | | This antibody is effective in immunoblotting, immunohistochemistry (IHC), immunoprecipitation (IP), and ELISA. |
| Suggested Working Dilution | | The optimal working dilution should be determined for each specific assay condition.
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| Storage | | Beta Amyloid, 1-16 (6E10) Monoclonal Antibody Low Endotoxin, Purified Exclusively Provided by CovanceStore at -20°C or below. Upon initial thawing, apportion into working aliquots and store at -20°C or below. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Do not store in frost-free freezers. |
| References | | Thakker DR, et al. Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. Proc Natl Acad Sci USA Feb 25, 2009. Klyubin I, et al. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med 11(5):556-61, 2005. Oddo S, et al. Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer’s disease. PNAS 102(8):3046-51, 2005. Fratta P, et al. Mutant ubiquitin UBB+1 is accumulated in sporadic inclusion-body myositis muscle fibers. Neurology 63:1114-1117, 2004. Funamoto S, et al. Truncated carboxyl-terminal fragments of beta- Amyloid precursor protein are processed to Amyloid beta-proteins 40 and 42. Biochem 43:13523-13540, 2004. Herzig M, et al. Abeta is targeted to the vasculature in a mouse model of heredity cerebral hemorrhage with amyloidosis. Nat. Neuro. 7(9):954-959, 2004. Kim KS, et al. Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide. Neurosci. Res. Comm. 2:121-130, 1988. Kim KS, et al. Neurosci. Res. Comm. 7:113, 1988. |
| Warranty/Conditions | | Covance products may not be resold or modified for resale without prior written approval. |
