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Stemolecule ALK5 Inhibitor

产品信息
    • Stemolecule ALK5 Inhibitor保存于运输说明：
    • Store at 4°C. Protect from light. Following reconstitution, store aliquots at -20°C
    • 详细信息：
    • Stemolecule™ ALK5 Inhibitor

       

      Stemolecule™ ALK5 Inhibitor is a selective and ATP-competitive inhibitor of a TGF-β family type I receptor, activin receptor-like kinase (ALK5)1. Inhibition of TGF-β signaling increased the efficiency of reprogramming of rat liver progenitor cells and IMR90 human fibroblast cells to mouse embryonic stem (ES) cell-like induced pluripotent stem (iPS) cells, as well as maintained these cells in an undifferentiated state for over 30 passages2. The mouse ES cell culture condition together with inactivation of TGF-β signaling provided a robust culturing method of reprogrammed rat and human iPS cells2. This study indicates the significant role of TGF-β signaling in regulating ES cell fate determination, and provides a novel method for culture of rat and human iPS cells.

      Stemolecule ALK5 Inhibitor产品参数

       

      Alternate Name 2-(3-(6-methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
      Chemical Formula C17H13N5
      Structure  
      Molecular Weight 287.32
      CAS Number NA
      Purity >99%
      Formulation Yellow solid
      Solubility Stemolecule ALK5 Inhibitor Soluble in DMSO (100 mM) or methanol (17 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 384 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.
      Storage Store at 4°C. Protect from light. Following reconstitution, store aliquots at -20°C
      Stability Stock solutions stable at -20°C for 6 months
      Quality Control The purity of Stemolecule ALK5 Inhibitor was determined by HPLC analysis. The accurate mass and structure of Stemolecule ALK5 Inhibitor was determined by mass spectrometry and NMR, respectively. Cellular toxicity of ALK5 Inhibitor was tested on HeLa and HEK293 cells.
      References
      1. Gellibert, F., Woolven, J., Fouchet, M. H., Mathews, N., Goodland, H., Lovegrove, V., Laroze, A., Nguyen, V. L., Sautet, S., Wang, R., Janson, C., Smith, W., Krysa, G., Boullay, V., De Gouville, A. C., Huet, S., and Hartley, D. (2004) Identification of 1, 5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem 47, 4494-506.
      2. Li, W., Wei, W., Zhu, S., Zhu, J., Shi, Y., Lin, T., Hao, E., Hayek, A., Deng, H., and Ding, S. (2008) Generation of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors. Cell Stem Cell 4, 16-19.
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