公司销售
大叶茜草素 55481-88-4售后服务中药标准品,还同时销售CP(中检所产品指定代理商)英国实验室LGC 医药杂质标准品、 加拿大TRC标准品 、EP(欧洲药典) 、USP(美国药典)、BP(英国药典) 、(WHO)世界卫生组织药物标准品 、NIST 、 美国Accustandard标准品,美国ChemService标准品等各种产品。种类齐全,到货迅速。更多详细信息欢迎您来电咨询!
产品中文名称:
大叶茜草素 55481-88-4售后服务中文别名: 6-羟基-2,2-二甲基苯并[h]苯并吡喃-5-羧酸甲酯
英文名: Mollugin
英文别名: Rubimaillin;,2-Dimethyl-6-hydroxy-2H-naphtho[1,2-b]pyran-5-carboxylic acid methyl ester
CAS登录号: 55481-88-4
分子式: C17H16O4
分子量: 284.31
分子结构:

外观: 黄色结晶
规格: 20 mg/支
纯度: ≥ 98%
用途: 用于含量测定/鉴定/药理实验等。
提取来源: 茜草科植物(Rubia cordifolia L.)的干燥根
溶解性: 可溶于苯、DMSO等溶剂,不溶于水。
熔点: 127-129℃
药理药效: 具有凉血、止血,HX去瘀等作用。
贮存条件: 4℃冷藏、密封、避光
有效期: 2年
产品名称 | 大叶茜草素 55481-88-4售后服务
|
英文名称 | Mollugin
|
包装 | 可根据客户要求订制 |
注意事项:
大叶茜草素 55481-88-4售后服务纯度高,检测/鉴别精确,稳定性强,为了防止产品含量降低,不宜暴露在空气中,应防潮、避光和抗氧化包装,保存应以提高物质稳定性为原则,尽可能在干燥、低温条件下储藏(液体或易潮解物质分装在熔封的玻璃安瓶内)。
规格:规格包装齐全可根据要求定制包装。
用途:产品供科研实验使用,详情可参照产品说明书。
运输:快递免费送货上门,全国各地现货供应。
大叶茜草素 55481-88-4售后服务不能直接用于人体,出库的产品全部经过严格的检测,保证质量。标准品/对照品一般用于鉴别、检查和含量 (或效价)测定。对于鉴别来说,只要确认未混淆标准物质 即可,而检查和含量测定则不同,大部分检查项目和含量测定项目均有明确的标准。这就要求在进行检验时要控制实验误差,在进行标准物质称量时未严格按照药典等标准要求进行。
examined with highest levels in brain, kidney, heart and spleen. Weak ex
pression in liver. In adult brain, highest ex
pression found in the fro
ntal lobe of the cortex and in the anterior perisylvian cortex-opercular gyri. Moderate ex
pression in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Weak ex
pression found in the striate, extra-striate and motor cortices. Expressed in cerebrospinal fluid, and plasma. Isoform APP695 is the predominant form in neuro
nal tissue, isoform APP751 and isoform APP770 are widely expressed in non-neuro
nal cells. Isoform APP751 is the most abundant form in T-lymphocytes. Appican is expressed in astrocytes.
Post-translatio
nal modifications : Proteolytically processed under normal cellular conditions. Cleavage either by alpha-secretase, beta-secretase or theta-secretase leads to generation and extracellular release of soluble APP peptides, S-APP-alpha and S-APP-beta, and the retention of correspo
nding membrane-anchored C-terminal fragments, C80, C83 and C99. Subsequent processing of C80 and C83 by gamma-secretase yields P3 peptides. This is the major secretory pathway and is non-amyloidogenic. Alternatively, presenilin/nicastrin-mediated gamma-secretase processing of C99 releases the amyloid beta proteins, amyloid-beta 40 (Abeta40) and amyloid-beta 42 (Abeta42), major compo
nents of amyloid plaques, and the cytotoxic C-terminal fragments, gamma-CTF(50), gamma-CTF(57) and gamma-CTF(59).
Proteolytically cleaved by caspases during neuro
nal apoptosis. Cleavage at Asp-739 by either caspase-6, -8 or -9 results in the production of the neurotoxic C31 peptide and the increased production of beta-amyloid peptides.
N- and O-glycosylated. O-l
inkage of cho
ndroitin sulfate to the L-APP isoforms produces the APP proteoglycan core proteins, the appicans. The cho
ndroitin sulfate chain of appicans co
ntains 4-O-sulfated galactose in the l
inkage region and cho
ndroitin sulfate E in the repeated disaccharide region.
Phosphorylation in the C-terminal on tyrosine, threo
nine and serine residues is neuron-specific. Phosphorylation can affect APP processing, neuro
nal differentiation and interaction with other proteins. Phosphorylated on Thr-743 in neuro
nal cells by Cdc5 kinase and Mapk10, in dividing cells by Cdc2 kinase in a cell-cycle dependent manner with maximal levels at the G2/M phase and, in vitro, by GSK-3-beta. The Thr-743 phosphorylated form causes a co
nformational change
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