产品中文名称:
长春碱 865-21-4价格中文别名: 长春花碱
英文名: vinblastine
英文别名: Vincaleukoblastine;VLB
CAS登录号: 865-21-4
分子式: C46H58N4O9
分子量: 810.97
长春碱 865-21-4价格分子结构:

外观: 白色针状结晶
规格: 20 mg/支
纯度: ≥ 98%
用途: 用于含量测定/鉴定/药理实验等。
提取来源: 夹竹桃科植物长春花
溶解性: 溶于***、丙酮和乙醇。
熔点: 211~216℃
旋光度: +42°(***)
药理药效: 用于ZL何杰金氏病和绒毛膜上皮癌,LX较好;对淋巴肉瘤、网状细胞肉瘤、急性白血病、乳腺癌、圣母细胞瘤、卵巢癌、睾丸癌、神经母细胞瘤和恶性黑色素瘤等也有一定LX .
贮存条件: 4℃冷藏、密封、避光
有效期: 2年
长春碱 865-21-4价格特点:是一种敏感性高,特异性强,重复性好的实验诊断方法,由于其试剂稳定、易保存,操作简便,结果判断较客观等因素,已广泛应用在免疫学检验的各领域中。
检测方式:相色谱法HPLC≥98%。
贮存条件:4℃冷藏、密封、避光。
包装:可根据客户需求提供相应批量包装。
用途:用于含量测定、鉴别、药理实验、活性筛选等。
长春碱 865-21-4价格标准品和对照品的本质区别:
所谓标准品,即是标准物品,作为一种衡量标准,如果用在药物方面,则为含量测定中的标准含量。标准品包括化学计量标准品、冶金标准品和药检标准品。采用生化方法来测定,目前国家规定的标准品共有15种,林可酶素、新霉素、大观酶素、太乐菌素、链霉素、卡那霉素、绒促性素、盐酶素、杆菌肽锌、安普酶素、红霉素、合成缩宫素、庆大霉素、渡毛化苷G。
所谓对照品,是指用于鉴别、检查、含量测定和校正检定仪器性能的标准物质。采用化学方法来测定,即是一般仪器的都叫做对照品,国家规定的有107种,包括地塞米松、土霉素、阿莫西林等等。
刺五加皂苷B和对照品一样是指国家药品标准中用于鉴别、检查、含量测定、杂质和有关物质检查等标准物质,它是国家药品标准不可分割的组成部分。
但刺五加皂苷B和对照品又是两个不同的概念,ZG药典凡例中有明确的定义:刺五加皂苷B是指用于生物鉴定、抗生素或生物药品中含量或效价测定的标准物质,以效价单位(U)表示,而对照品系指用于鉴别、检查、含量测定和校正检定仪器性能的标准物质。文献中经常混淆了这两个概念,认为刺五加皂苷B就是对照品,是同种物质的不同提法,之所以会有这样的误解,可能是有的药品既有刺五加皂苷B,又有对照品。例如,非那西丁当用作熔点校准物质时,用熔点刺五加皂苷B,测定含量时,用对照品;当用微生物法测定头孢克罗效价时,用头孢克罗刺五加皂苷B,用HPLC或U刺五加皂苷B法测定时,则用对照品。
proteins are structured similarly each composed of an N-terminal domain with multiple ankyrin repeats, a highly co
nserved central spectrin binding domain, and C-terminal regulatory domains which are susceptible to the most variance. Both Ankyrin B and Ankyrin G are essential for normal neuro
nal functions. Ankyrin B, or brain Ankyrin is predominantly expressed in the plasma membrane of neurons as well as glial cells throughout the brain. Two trans
cripts have been described with alternative splicing resulting in additio
nal isoforms. The Ankyrin B protein associates with the spectrin-actin network, mediates axon fasciculation, and stabilizes axon bundles. Ankyrin B is required for coordinated assembly of Na/Ca exchanger, Na/K ATPase, and inositol trisphosphate (InsP(3)) receptor at transverse-tubule/sarcoplasmic reticulum sites in cardiomyocytes.
Function : Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated ex
pression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner segment of rod photoreceptors. Required for ex
pression and targeting of SPTBN1 in neo
natal cardiomyocytes and for the regulation of neo
natal cardiomyocyte co
ntraction rate.
Subunit : Interacts with RHBG and SPTBN1.
Subcellular Location : Cytoplasm, cytoskeleton. Membrane. Cytoplasm, myofibril, sarcomere, M line. Apical cell membrane. Cell membrane.
Tissue Specificity : Present in plasma membrane of neurons as well as glial cells throughout the brain. Expressed in fetal brain and in temporal cortex of adult brain. Also expressed in the inner segments of rod photoreceptors in retina.
DISEASE : Defects in ANK2 are the cause of long QT syndrome type 4 (LQT4) [MIM:600919]; also known as sick sinus syndrome with bradycardia. Long QT syndromes are heart disorders characterized by a prolo
nged QT
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