川陈皮素478-01-3图片特点:是一种敏感性高,特异性强,重复性好的实验诊断方法,由于其试剂稳定、易保存,操作简便,结果判断较客观等因素,已广泛应用在免疫学检验的各领域中。
产品中文名称:
川陈皮素478-01-3图片中文别名: 川皮亭;蜜橘黄素
英文名: Nobiletin
英文别名: 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one
CAS登录号: 478-01-3
分子式: C21H22O8
分子量: 402.39
川陈皮素478-01-3图片分子结构:
外观: 无色晶体
规格: 20 mg/支
纯度: ≥ 98%
用途: 用于含量测定/鉴定/药理实验等。
提取来源: 芸香科川橘 Citrus nobilis Lour.果皮
溶解性: 可溶于DMSO、***和甲醇的混合溶剂,微溶于水和***,不溶于石油醚。
熔点: 137-138℃
药理药效: 具有抗血细胞凝集、抗血栓形成、、抗真菌、KY、抗过敏、抗胆碱酯酶和抗癫痫作用,碳水化合物代谢促进剂
贮存条件: 4℃冷藏、密封、避光
有效期: 2年
川陈皮素478-01-3图片标准品和对照品的本质区别:
所谓标准品,即是标准物品,作为一种衡量标准,如果用在药物方面,则为含量测定中的标准含量。标准品包括化学计量标准品、冶金标准品和药检标准品。采用生化方法来测定,目前国家规定的标准品共有15种,林可酶素、新霉素、大观酶素、太乐菌素、链霉素、卡那霉素、绒促性素、盐酶素、杆菌肽锌、安普酶素、红霉素、合成缩宫素、庆大霉素、渡毛化苷G。
所谓对照品,是指用于鉴别、检查、含量测定和校正检定仪器性能的标准物质。采用化学方法来测定,即是一般仪器的都叫做对照品,国家规定的有107种,包括地塞米松、土霉素、阿莫西林等等。
刺五加皂苷B和对照品一样是指国家药品标准中用于鉴别、检查、含量测定、杂质和有关物质检查等标准物质,它是国家药品标准不可分割的组成部分。
但刺五加皂苷B和对照品又是两个不同的概念,ZG药典凡例中有明确的定义:刺五加皂苷B是指用于生物鉴定、抗生素或生物药品中含量或效价测定的标准物质,以效价单位(U)表示,而对照品系指用于鉴别、检查、含量测定和校正检定仪器性能的标准物质。文献中经常混淆了这两个概念,认为刺五加皂苷B就是对照品,是同种物质的不同提法,之所以会有这样的误解,可能是有的药品既有刺五加皂苷B,又有对照品。例如,非那西丁当用作熔点校准物质时,用熔点刺五加皂苷B,测定含量时,用对照品;当用微生物法测定头孢克罗效价时,用头孢克罗刺五加皂苷B,用HPLC或U刺五加皂苷B法测定时,则用对照品。
overex
pression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA (By similarity). Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level.
Function : May act in negative regulation of cell growth and transformation by interacting with no
nreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus(v-Abl) after overex
pression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA (By similarity). Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level.
Subunit : Interacts with ABL1, ENAH, STX1A, SNAP25, VAMP2, EPS8, and through its N-terminus with WASF1. Part of a complex co
nsisting of ABI1, STX1A and SNAP25. Part of a complex co
nsisting of ABI1, EPS8 and SOS1 (By similarity). Interacts with SOS1, SOS2, GRB2, SPTA1 and the first SH3 domain of NCK1. Isoform 6 does not interact with NCK1. Compo
nent of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2.
Subcellular Location : Cytoplasm (By similarity). Nucleus (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, filopodium (By similarity). Cell projection, growth cone (By similarity). Cell junction, synapse, synaptosome (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Localized to protruding lamellipodia and filopodia
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