Cynomolgus CD3 epsilon & CD3 delta Heterodimer Protein, His Tag & Flag Tag

内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>92% as determined by SDS-PAGE.

活性:


产品背景:
T-cell surface glycoprotein CD3 delta & CD3 epsilon chain, also known as CD3D & CD3E or CD3D&CD3E respectively, are single-pass type I membrane proteins. CD3D, together with CD3- epsilon(CD3E) , CD3-gamma and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.

产品描述:
The heterodimer Cynomolgus CD3E & CD3D heterodimer is produced by co-expression of CD3E and CD3D, has a calculated MW of 15.5 kDa (CD3E) and 14.5 kDa (CD3D). Subunit CD3E is fused with his tag at the C-terminus and subunit CD3D is fused with flag tag at the C-terminus. The predicted N-terminus is Gln 22 (CD3E) and Phe 22 (CD3D). The reducing (R) heterodimer protein migrates as 18-20 kDa and 25-40 kDa due to glyosylation.