L-甘露糖CAS号：10030-80-5

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L-甘露糖CAS号：10030-80-5   
英文名称：L-Mannose；L-(?)-Mannose   
其他名称：L(-)-甘露糖   
CAS号：10030-80-5   
C6H12O6=180.16   
级别：AR   
含量：≥99%   
性状(以下信息仅供参考)：白色或类白色粉末。溶于水，熔点129～131℃   
用途：本品仅供科研，不得用于其它用途   
保存：RT 客户根据L-甘露糖CAS号：10030-80-5性质、化学式、分子式、结构式、比重、密度、CAS号、沸点、熔点、水溶性、MSDS、用途、作用、规格包装、性状、注意事项、英文名、别称、纯度、级别等情况，本产品化学性质稳定，运输条件不苛刻，一般储存在阴凉，干燥，通风良好的地方，远离不相容的物质。保持容器密闭。
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产品介绍 Known to be prominent in bacteria, D amino acids were generally thought to be absent in mammals. D-serine has since been found in high levels in the mammalian brain and in various mammalian fluids. D-serine activates N-methyl-D-aspartate (NMDA) receptors--molecules with important roles in learning, brain growth and brain cell death. Serine racemase is the enzyme catalyzing the formation of D-serine from L-serine. Serine racemase is a member of the family of pyridoxal-5’ phosphate-dependent enzymes and is localized to glial cells in rat brain.
Function : Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
Subunit : Homodimer.
Tissue Specificity : Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart, skeletal muscle, kidney and liver.
Post-translational modifications : S-nitrosylated, leading to decrease the enzyme activity.
Similarity : Belongs to the serine/threonine dehydratase family.
Database links : UniProtKB/Swiss-Prot: Q9GZT4.1
英文名称  Anti-SPR/Sepiapterin reductase
中文名称  墨蝶蛉还原酶抗体
别    名  SDR38C1; Sepiapterin reductase (7,8 dihydrobiopterin:NADP+ oxidoreductase); Sepiapterin reductase; Short chain dehydrogenase/reductase family 38C, member 1; SPR; SPRE_HUMAN.
浓    度  1mg/1ml
规 格  0.2ml/200μg
L-甘露糖CAS号：10030-80-5抗体来源  Rabbit 
克隆类型  polyclonal
交叉反应  Human, Mouse, Rat, Pig, Horse, Rabbit
产品类型  一抗   
研究领域  肿瘤 细胞生物 神经生物学 信号转导 新陈代谢 
蛋白分子量  predicted molecular weight: 28kDa
性    状  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human Sepiapterin reductase
亚    型  IgG
纯化方法  affinity purified by Protein A
储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蜡切片需做抗原修复）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 SPR, also known as sepiapterin reductase, is a homodimeric cytoplasmic protein that belongs to the sepiapterin reductase family. SPR functions as an NADH-dependent aldo-keto reductase and specifically catalyzes the reduction of pteridine derivatives. In addition, SPR plays an important role in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the final reduction step of the synthesis pathway. BH4 is an essential cofactor for the hydroxylation of the aromatic amino acids (tryptophan, tyrosine and phenylalanine) and is required for proper dopamine synthesis. Mutations in the gene encoding SPR can cause sepiapterin reductase deficiency, a monoamine neurotransmitter deficiency without hyperphenylalaninemia. Sepiapterin reductase deficiency interferes with BH4 synthesis, resulting in DOPA-responsive dystonia and a variety of other human diseases. In addition, SPR mRNA expression is increased in the brain of Parkinson’s Disease (PD) patients, suggesting that SPR may play a role in PD.
Function : Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
Subunit : Homodimer.
Subcellular Location : Cytoplasm.
Post-translational modifications : In vitro phosphorylation of Ser-213 by CaMK2 does not change kinetic parameters.
DISEASE : Defects in SPR are the cause of dystonia DOPA-responsive due to sepiapterin reductase deficiency (DRDSPRD) [MIM:612716]. In the majority of cases, patients manifest progressive psychomotor retardation, dystonia and spasticity. Cognitive anomalies are also often present. The disease is due to severe dopamine and serotonin deficiencies in the central nervous system caused by a defect in BH4 synthesis. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.
Similarity : Belongs to the sepiapterin reductase family.
Database links : UniProtKB/Swiss-Prot: P35270.1
英文名称  Anti-alpha + beta Synuclein
中文名称  核突触蛋白α+β抗体
别    名  Alpha synuclein; Beta synuclein; NACP; Non A beta component of AD amyloid; Non A4 component of amyloid precursor; PARK1; PARK4; Parkinson disease familial 1; PD1; SNCA; SYUA_HUMAN; SNCB; SNCB protein; Synuclein alpha; Synuclein beta; SYUB_HUMAN.
浓    度  1mg/1ml
规 格  0.1ml/100μg  0.2ml/200μg
抗体来源  Rabbit 
克隆类型  polyclonal
交叉反应  Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, zebrafinch 
产品类型  一抗   
研究领域  细胞生物 神经生物学 Alzheimer's 
蛋白分子量  predicted molecular weight: 14kDa
性    状  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human alpha + beta Synuclein
亚    型  IgG
纯化方法  affinity purified by Protein A
储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蜡切片需做抗原修复）