Anti-AATF抗体,拮抗凋亡转录因子抗体说明书

     Anti-AATF抗体,拮抗凋亡转录因子抗体说明书产品详细资料

产品编号 BYK-1229R

英文名称 AATF
中文名称 拮抗凋亡转录因子抗体
别    名 Apoptosis antagonizing transcription factor; CHE1; DED; AATF; AATF_HUMAN; Apoptosis-antagonizing transcription factor; Rb-binding protein Che-1; Protein AATF;Rb binding protein Che 1.
研究领域 肿瘤  细胞生物  免疫学  染色质和核信号  细胞凋亡  转录调节因子  表观遗传学  
分 子 量 63kDa
细胞定位 细胞核  

抗体来源 Mouse or Rabbit
克隆类型 Monoclonal or Polyclonal
产品应用 WB、ELISA、IHC-P、IHC-F、Flow-Cyt、IF、IP、ICC 此产品应用不做依据，具体产品应用与实验稀释比请！

not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

性    状 Lyophilized or Liquid
浓    度 1mg/1ml
亚    型 IgG
纯化方法 affinity purified by Protein G
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.


     Anti-AATF抗体,拮抗凋亡转录因子抗体说明书产品介绍 

      The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.

Function:
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

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