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(Gly¹,Ser³·²²,Gln⁴·³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³·³¹,Aib³²)-Pancreatic Polypeptide (human) trifluoroacetate salt

产品信息
  • 规格:0.5mg产品价格:5250.00
    规格:1mg产品价格:9450.00
    Catalog Number H-5088
    Synonyms (Gly¹,Gln⁴·¹⁶,Thr⁶·¹³,Tyr⁷,Asp¹⁰,Asn¹¹,Pro¹⁴,Arg²⁶,Met³⁰,Ala³¹,Aib³²)-Neuropeptide Y (human, rat)
    Molecular Formula C₁₈₃H₂₈₁N₅₇O₅₄S₂
    Relative Molecular Mass 4207.73
    CAS Registry Number [313988-89-5] net
    Source Synthetic
    Storage Conditions -20 ± 5 °C
    Areas of Interest Obesity Research
    产品描述
    This (Ala-Aib)-containing pancreatic peptide/neuropeptide Y chimera is a highly selective neuropeptide Y₅ receptor agonist. At this receptor this compound turned out to be 25-fold more potent than the derivative H-5084 (0.24 nM vs 6 nM) and three-fold more potent than the native ligand neuropeptide Y (H-6375) (0.24 nM vs 0.6 nM). This analog turned out to increase feeding approximately 2.5-fold more effective than neuropeptide Y.
    论文引用
    • A.Santos-Carvalho et al., Cell Death Dis., 4, e636 (2013)
    • S.Baptista et al., Neuropharmacology, 62, 2413 (2012)
    • A.P.Silva et al., J. Neurochem., 93, 163 (2005)
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    原装进口,(Gly¹,Ser³·²²,Gln⁴·³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³·³¹,Aib³²)-Pancreatic Polypeptide (human) trifluoroacetate salt,bachem品Pai大包装更优惠!
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