| 规格： | 0.5mg | 产品价格： | 1020.00 |
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| 规格： | 1mg | 产品价格： | 1455.00 |
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Catalog Number H-2958
Synonyms β-Amyloid (1-16), human
Molecular Formula C₈₄H₁₁₉N₂₇O₂₈
Relative Molecular Mass 1955.03
CAS Registry Number [131580-10-4] net
One Letter Code DAEFRHDSGYEVHHQK
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Alzheimer's Disease
产品描述
The Cu²⁺ complex of this soluble amyloid β-protein fragment showed significant oxidative activities toward the catechol-like substrate 1,2,3-trihydroxylbenzene (pyrogallol) and plasmid DNA cleavage.
The N-terminal Aβ fragments Aβ1-14 (H-7372), Aβ1-15 (H-6368), and Aβ1-16 are elevated in cell media and in CSF in response to γ-secretase inhibitor treatment. The fragments can serve as biomarkers in clinical studies of the effect of such inhibitors.
论文引用
• M.Hanenberg et al., J. Biol. Chem., 289, 27080 (2014)
• Y.Lu et al., J. Am. Soc. Mass Spectrom., 24, 454 (2013)
• M.Kamali-Moghaddam et al., BMC Neurosci., 11, 124 (2010)
• Y.Lu et al., Metallomics, 2, 474 (2010)
• W.Ni et al., Anal. Chem., 82, 7485 (2010)
• E.Portelius et al., Mol. Neurodegener., 5, 2 (2010)
• J.W.Karr and V.A.Szalai, Biochemistry, 47, 5006 (2008)
• R.Liu et al., J. Neurosci. Res., 75, 162 (2004)
• R.Liu et al., Biochemistry, 43, 9999 (2004)
• R.Liu et al., Biochemistry, 43, 6959 (2004)
• A.M.Szczepanik et al., J. Neurochem., 77, 304 (2001)
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温馨提示：不可用于临床ZL。
