Mdm4-binding Protein (MDM4) (N-Term) 抗体抗原
Mdm4-binding Protein (MDM4)
别名 mdmx, HDMX, MDMX, MRP1, wu:fa09h09, wu:fi33d10, 4933417N07Rik, AA414968, AL023055, AU018793, AU021806, C85810, Mdmx
抗原表位
其他选择 N-Term
适用
其他选择 人
宿主
其他选择 兔
克隆类型
多克隆
标记
其他选择 非结合性
应用范围
其他选择 Western Blotting (WB)
Pubmed 找到1个引用
规格 50 μg
发货至 ZG (更改)
发货时间 9至12个工作日
产品编号 yb184182
产品细节
Mdm4-binding Protein (MDM4) (N-Term) 抗体免疫原 Synthetic peptide directed towards the N terminal of human MDM4
序列 IPSQDQLKQS AEESSTSRKR TTEDDIPTLP TSEHKCIHSR EDEDLIENLA
预测反应 Human : 100 %, Dog : 90 %, Horse : 90 %, Pig : 80 %, Bovine : 80 %, Rabbit : 80 %
产品特性 This is a rabbit polyclonal antibody against MDM4. It was validated on Western Blot using a cell lysate as a positive control.
纯化方法 Affinity Purified
目标详细情况
Mdm4-binding Protein (MDM4) (N-Term) 抗体别名 MDM4
背景 MDM4 inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. It inhibits degradation of MDM2. It can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions. The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2.
分子量 55 kDa
基因ID 4194
NCBI登录号 NP_002384, NM_002393
UniProt O15151
使用细节
Mdm4-binding Protein (MDM4) (N-Term) 抗体应用备注 Optimal working dilutions should be determined experimentally by the investigator.
说明
Antigen size: 490 AA
限制 仅限研究用
贮存及处理
Mdm4-binding Protein (MDM4) (N-Term) 抗体状态 Lyophilized
溶解方式 Add 50 µL of distilled water.
浓度 1 mg/mL
缓冲液 PBS buffer with 2 % sucrose
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 For longer periods of storage, store at -20 °C
