Irbesartan ≥98%|CAS:138402-11-6|1 g|5 g|25 g

Aprovel, Avapro|Irbesartan is an angiotensin II (ATII) type 1 receptor inhibitor that also activates PPAR receptors; it exhibits antihypertensive, cardioprotective, and anti-hyperlipidemic activities. In angiotensin-converting enzyme 2 (ACE2)-deficient mice, irbesartan decreases TGF- 1, atrial natriuretic factor, collagen, and phospho-ERK1/2 expression and increases PPAR expression, reversing cardiac hypertrophy and myocardial fibrosis. In animal models of angiotensin II (ATII)-mediated abdominal aortic aneurysm, irbesartan prevents macrophage infiltration, pro-inflammatory cytokine release, smooth muscle attenuation, and medial elastolysis, and also limits aneurysm enlargement. In obese hypertensive rats, this compound decreases plasma levels of free fatty acids, triglycerides, and insulin; it also upregulates expression of hepatic PPAR . In high fat diet rats, irbesartan decreases body weight and adipose tissue weight and improves glucose metabolism and vascular function. |C25H28N6O|428.53||Ambient|